M
Mun Kyung Hwang
Researcher at Seoul National University
Publications - 24
Citations - 1701
Mun Kyung Hwang is an academic researcher from Seoul National University. The author has contributed to research in topics: Kinase & Protein kinase A. The author has an hindex of 20, co-authored 24 publications receiving 1489 citations. Previous affiliations of Mun Kyung Hwang include University of Minnesota & Konkuk University.
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Journal ArticleDOI
Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
Fred C. Lam,Stephen W. Morton,Jeffrey Wyckoff,Tu-Lan Vu Han,Mun Kyung Hwang,Amanda Maffa,Elena Balkanska-Sinclair,Michael B. Yaffe,Scott R. Floyd,Paula T. Hammond +9 more
TL;DR: The ability of Tf-NPs to traverse intact BBB in mice as well as achieve direct tumor binding in two intracranial orthotopic models of GBM are shown, demonstrating the preclinical potential of this nanoscale platform to deliver novel combination therapies to gliomas and other central nervous system tumors.
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Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression
Nam Joo Kang,Ki Won Lee,Bong Jik Shin,Sung Keun Jung,Mun Kyung Hwang,Mun Kyung Hwang,Ann M. Bode,Yong-Seok Heo,Hyong Joo Lee,Zigang Dong +9 more
TL;DR: It is found that Fyn, one of the members of the non-receptor protein tyrosine kinase family, was required for ultraviolet (UV) B-induced cyclooxygenase-2 (COX-2) expression, and caffeic acid suppressed UVB-induced skin carcinogenesis by directly inhibiting Fyn kinase activity.
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Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine.
Ki Won Lee,Nam Joo Kang,Nam Joo Kang,Yong-Seok Heo,Evgeny A. Rogozin,Angelo Pugliese,Mun Kyung Hwang,G. Tim Bowden,Ann M. Bode,Hyong Joo Lee,Zigang Dong +10 more
TL;DR: It is reported that red wine extract or the red wine flavonoid quercetin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transformation of JB6 promotion-sensitive mouse skin epidermal (JB6 P+) cells.
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Luteolin Inhibits Protein Kinase Cε and c-Src Activities and UVB-Induced Skin Cancer
Sanguine Byun,Ki Won Lee,Sung Keun Jung,Sung Keun Jung,Sung Keun Jung,Eun-Jung Lee,Mun Kyung Hwang,Mun Kyung Hwang,Sung Hwan Lim,Ann M. Bode,Hyong Joo Lee,Zigang Dong +11 more
TL;DR: Analysis of the skin and immunoblotting data suggest that luteolin exerts potent chemopreventive activity against UVB-induced skin cancer mainly by targeting PKC(epsilon)and Src.
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Protective Effect of Quercetin against Arsenite-Induced COX-2 Expression by Targeting PI3K in Rat Liver Epithelial Cells
Kyung Mi Lee,Kyung Mi Lee,Mun Kyung Hwang,Mun Kyung Hwang,Dong Eun Lee,Dong Eun Lee,Ki Won Lee,Hyong Joo Lee +7 more
TL;DR: It is demonstrated that COX-2 expression and PGE(2) secretion are up-regulated by arsenite in rat liver epithelial (RLE) cells, and quercetin suppresses arsenite-induced COX2 expression mainly by blocking the activation of the PI3K signaling pathway, which may contribute to its chemopreventive potential.