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Gabriele Ludewig
Researcher at University of Iowa
Publications - 76
Citations - 2722
Gabriele Ludewig is an academic researcher from University of Iowa. The author has contributed to research in topics: Metabolite & Oxidative stress. The author has an hindex of 29, co-authored 73 publications receiving 2390 citations. Previous affiliations of Gabriele Ludewig include Vanderbilt University & University of Mainz.
Papers
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Journal ArticleDOI
Metabolism and metabolites of polychlorinated biphenyls
Fabian A. Grimm,Dingfei Hu,Izabela Kania-Korwel,Hans-Joachim Lehmler,Gabriele Ludewig,Keri C. Hornbuckle,Michael W. Duffel,Åke Bergman,Larry W. Robertson +8 more
TL;DR: An overview of PCB metabolism is provided, and mammalian metabolism of PCBs and their hydroxyl, methylsulfonyl, and sulfated metabolites, especially those that persist in human blood are discussed.
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Production of DNA Strand Breaks in Vitro and Reactive Oxygen Species in Vitro and in HL-60 Cells by PCB Metabolites
TL;DR: It is concluded that dihydroxylated PCBs, and PCB quinones after reaction with GSH, produce superoxide and other ROS both in vitro and in HL-60 cells, and oxidative DNA damage in the form of DNA strand breaks in vitro.
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Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells
Yong Xu,Krishnan A,Wan Xs,Hideyuki J. Majima,Che-Chung Yeh,Gabriele Ludewig,Edward J. Kasarskis,St Clair Dk +7 more
TL;DR: The results suggest that the reduced level of MnSOD expression in some tumor cells is, at least in part, due to a defect in the DNA sequence of the promoter region.
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A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells.
TL;DR: The results indicate that the high level of survivin in some cancers is, at least in part, due to a genetic defect in the promoter region of the human survivin gene, which causes derepression of Survivin transcription apparently due to the mutated CDE/CHR repressor binding motifs.
Book
Polychlorinated biphenyls and polybrominated biphenyls
Antonio Agudo,Kristan J. Aronson,Eva Cecilie Bonefeld-Jørgensen,Pierluigi Cocco,Vincent Cogliano,Jean Pierre Cravedi,Harald L. Esch,Heidelore Fiedler,Howard P. Glauert,Yueliang Leon Guo,Ronald A. Herbert,Nancy B. Hopf,Margaret O. James,Niklas Johansson,Bruno Le Bizek,Gabriele Ludewig,Miroslav Machala,Franco Merletti,Jean-François Narbonne,Larry W. Robertson,Avima M. Ruder,Helen Tryphonas,Roel Vermeulen,Katrin Vorkamp,Nigel J. Walker,David O. Carpenter +25 more
TL;DR: In this article, the IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (WG-7) presented a review of polychlorinated biphenyls and polybrominated biphexyls.