G
Gabriella Huerta
Researcher at Pfizer
Publications - 4
Citations - 993
Gabriella Huerta is an academic researcher from Pfizer. The author has contributed to research in topics: Blood–brain barrier & B cell. The author has an hindex of 4, co-authored 4 publications receiving 897 citations.
Papers
More filters
Journal ArticleDOI
Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire
Jacob Glanville,Wenwu Zhai,Jan Berka,Dilduz Telman,Gabriella Huerta,Gautam R. Mehta,Irene Ni,Li Mei,Purnima Sundar,Giles Day,David Cox,Arvind Rajpal,Jaume Pons +12 more
TL;DR: A general method for assessing human antibody sequence diversity displayed on phage using massively parallel pyrosequencing, a novel application of Kabat column-labeled profile Hidden Markov Models, and translated complementarity determining region (CDR) capture-recapture analysis is presented.
Journal ArticleDOI
B cell exchange across the blood-brain barrier in multiple sclerosis
H.-Christian von Büdingen,Tracy C. Kuo,Marina Sirota,Christopher van Belle,Leonard Apeltsin,Jacob Glanville,Bruce A.C. Cree,Pierre-Antoine Gourraud,Amy Schwartzburg,Gabriella Huerta,Dilduz Telman,Purnima Sundar,Tyler Casey,David Cox,Stephen L. Hauser +14 more
TL;DR: In this paper, the authors applied deep repertoire sequencing of IgG heavy chain variable region genes (IgG-VH) in paired cerebrospinal fluid and PB samples from patients with MS and other neurological diseases to identify related B cells that are common to both compartments.
Journal ArticleDOI
Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation
Jacob Glanville,Tracy C. Kuo,H.-Christian von Büdingen,Lin Guey,Jan Berka,Purnima Sundar,Gabriella Huerta,Gautam R. Mehta,Jorge R. Oksenberg,Stephen L. Hauser,David Cox,Arvind Rajpal,Jaume Pons +12 more
TL;DR: Using high-throughput sequence analysis of monozygotic twins, it is shown that variation in naive VH and DH segment use is strongly determined by an individual's germ-line genetic background and may provide a unique mechanism for stratifying individual risk profiles in specific diseases.
Journal Article
B Cell Exchange across the Blood-Brain Barrier in Multiple Sclerosis (S11.003)
H. Von Budingen,Tracy C. Kuo,Marina Sirota,Christopher van Belle,Leonard Apeltsin,Jacob Glanville,Bruce A.C. Cree,Pierre-Antoine Gourraud,Amy Schwartzburg,Gabriella Huerta,Dilduz Telman,Purnima Sundar,Tyler Casey,David G. Cox,Stephen L. Hauser +14 more
TL;DR: Deep repertoire sequencing of IgG heavy chain variable region genes in paired cerebrospinal fluid and PB samples from patients with MS and other neurological diseases found that a restricted pool of clonally related B cells participated in robust bidirectional exchange across the BBB, suggesting that CNS-directed autoimmunity may be triggered and supported on both sides of theBBB.