Marina Sirota

TL;DR: These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution.

TL;DR: GERP++ is an efficient and effective tool to provide both nucleotide- and element-level constraint scores within deep multiple sequence alignments, and is predicted to predict a higher fraction than earlier estimates largely due to the annotation of longer constrained elements, which improves one to one correspondence between predicted elements with known functional sequences.

TL;DR: The evolution of knowledge base–driven pathway analysis over its first decade is discussed, distinctly divided into three generations, and a number of annotation challenges that must be addressed to enable development of the next generation of pathway analysis methods are identified.

TL;DR: A systematic analysis using different measurement modalities of tumour purity in >10,000 samples across 21 cancer types from the Cancer Genome Atlas finds an immunotherapy gene signature in several cancer types that is not detected by traditional differential expression analyses.

TL;DR: A systematic computational approach to predict novel therapeutic indications on the basis of comprehensive testing of molecular signatures in drug-disease pairs for repositioning established drugs to treat a wide range of human diseases.