H
H.-Christian von Büdingen
Researcher at University of California, San Francisco
Publications - 28
Citations - 1804
H.-Christian von Büdingen is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 15, co-authored 21 publications receiving 1300 citations. Previous affiliations of H.-Christian von Büdingen include University of Zurich & Technische Universität München.
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Journal ArticleDOI
Update on the Autoimmune Pathology of Multiple Sclerosis: B-Cells as Disease-Drivers and Therapeutic Targets
H.-Christian von Büdingen,Arumugam Palanichamy,Klaus Lehmann-Horn,Brady Michel,Scott S. Zamvil +4 more
TL;DR: The goal of this review is to summarize how B-cells may contribute to MS pathogenesis and thereby provide a basis for understanding why B-cell depletion is so effective in the treatment of this disease.
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Rituximab Efficiently Depletes Increased CD20-Expressing T Cells in Multiple Sclerosis Patients
Arumugam Palanichamy,Sarah Jahn,Dorothee Nickles,Mia Derstine,Aya Abounasr,Stephen L. Hauser,Sergio E. Baranzini,David Leppert,H.-Christian von Büdingen +8 more
TL;DR: It is shown that in MS patients, increased levels of CD3+CD20dim T cells are effectively depleted by RTX, and depletion of CD20-expressing T cells may also contribute to the therapeutic effect of RTX and other mAbs targeting CD20.
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B cell exchange across the blood-brain barrier in multiple sclerosis
H.-Christian von Büdingen,Tracy C. Kuo,Marina Sirota,Christopher van Belle,Leonard Apeltsin,Jacob Glanville,Bruce A.C. Cree,Pierre-Antoine Gourraud,Amy Schwartzburg,Gabriella Huerta,Dilduz Telman,Purnima Sundar,Tyler Casey,David Cox,Stephen L. Hauser +14 more
TL;DR: In this paper, the authors applied deep repertoire sequencing of IgG heavy chain variable region genes (IgG-VH) in paired cerebrospinal fluid and PB samples from patients with MS and other neurological diseases to identify related B cells that are common to both compartments.
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Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis.
Arumugam Palanichamy,Leonard Apeltsin,Tracy C. Kuo,Marina Sirota,Sheng-zhi Wang,Steven J. Pitts,Purnima Sundar,Dilduz Telman,Lora Z. Zhao,Mia Derstine,Aya Abounasr,Stephen L. Hauser,H.-Christian von Büdingen +12 more
TL;DR: Pinpointing Ig class-switched B cells as key component of the immune axis thought to contribute to ongoing MS disease activity strengthens the rationale of current B cell–targeting therapeutic strategies and may lead to more targeted approaches.
Journal ArticleDOI
Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation
Jacob Glanville,Tracy C. Kuo,H.-Christian von Büdingen,Lin Guey,Jan Berka,Purnima Sundar,Gabriella Huerta,Gautam R. Mehta,Jorge R. Oksenberg,Stephen L. Hauser,David Cox,Arvind Rajpal,Jaume Pons +12 more
TL;DR: Using high-throughput sequence analysis of monozygotic twins, it is shown that variation in naive VH and DH segment use is strongly determined by an individual's germ-line genetic background and may provide a unique mechanism for stratifying individual risk profiles in specific diseases.