Gadiparthi N. Rao

TL;DR: These findings demonstrate for the first time that hydrogen peroxide, a cellular oxidant, possess the ability to activate EGFR-mediated signaling events in VSMC, which may be important in oxidant stress-induced cellular responses.

TL;DR: Data demonstrate that 4-hydroxy-2-nonenal (HNE), one of several important lipid peroxidation products, induces rat aortic smooth muscle cell growth through redox-sensitive mechanisms and growth factor expression, consistent with a role for lipid per oxidation products in vascular smooth Muscle cell growth in atherogenesis.

TL;DR: Findings suggest a role for tyrosine phosphorylation of IGF-IRβ, IRS-1, and PLC-γ1 in thrombin-induced mitogenic signaling events in VSMC and suggest that Src may be involved in the cross-talk between the G-protein-coupled receptor agonist and a tyrosin kinase receptor such as IGF-1R.

TL;DR: A role for NADH/NADPH oxidase activity in some subset of early signaling events such as p38 MAP kinase activation and c-Fos and JunB induction, which appear to be important in agonist-induced AP-1 activity and DNA synthesis in VSMC are suggested.

TL;DR: It is suggested that hydrogen peroxide induces the production of eicosanoids and that the eicOSanoids are potential mediators of the oxidative stress-stimulated growth-related events in vascular smooth muscle cells.