G
Gaëlle Pérot
Researcher at French Institute of Health and Medical Research
Publications - 26
Citations - 1821
Gaëlle Pérot is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Sarcoma & Anaplastic lymphoma kinase. The author has an hindex of 18, co-authored 25 publications receiving 1494 citations. Previous affiliations of Gaëlle Pérot include Argonne National Laboratory & Curie Institute.
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Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity
Frédéric Chibon,Pauline Lagarde,Sébastien Salas,Gaëlle Pérot,Véronique Brouste,Franck Tirode,Carlo Lucchesi,Aurélien de Reyniès,Audrey Kauffmann,Binh Bui,Philippe Terrier,Sylvie Bonvalot,Axel Le Cesne,Dominique Vince-Ranchère,Jean-Yves Blay,F. Collin,Louis Guillou,Agnès Leroux,Jean-Michel Coindre,Alain Aurias +19 more
TL;DR: A prognostic gene expression signature, complexity index in sarcomas (CINSARC), composed of 67 genes related to mitosis and chromosome management, is established, which predicts metastasis outcome and predicts outcome for gastrointestinal stromal tumors, breast carcinomas and lymphomas.
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Chromosome Instability Accounts for Reverse Metastatic Outcomes of Pediatric and Adult Synovial Sarcomas
Pauline Lagarde,Joanna Przybyl,Céline Brulard,Gaëlle Pérot,Gaëlle Pierron,Olivier Delattre,Raf Sciot,Agnieszka Wozniak,Patrick Schöffski,Philippe Terrier,Agnès Neuville,Jean-Michel Coindre,Antoine Italiano,Daniel Orbach,Maria Debiec-Rychter,Frédéric Chibon +15 more
TL;DR: Comparing genomic profiles of adult versus pediatric SS, it is shown that metastasis is associated with genome complexity in both situations and that the adult genome is more frequently rearranged, Accordingly, pediatric patients with an even genomic profile do not develop metastasis.
Journal ArticleDOI
Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors.
Pauline Lagarde,Gaëlle Pérot,Audrey Kauffmann,Céline Brulard,Valérie Dapremont,Isabelle Hostein,Agnès Neuville,Agnieszka Wozniak,Raf Sciot,Patrick Schöffski,Alain Aurias,Jean Michel Coindre,Maria Debiec-Rychter,Frédéric Chibon +13 more
TL;DR: A high Genomic Index determined by comparative genomic hybridization from formalin-fixed, paraffin-embedded samples could be used to identify AFIP intermediate-risk patients who would benefit from imatinib therapy.
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Remarkable Response to Crizotinib in Woman With Anaplastic Lymphoma Kinase–Rearranged Anaplastic Thyroid Carcinoma
Yann Godbert,Bénédicte Henriques de Figueiredo,Françoise Bonichon,Frédéric Chibon,Isabelle Hostein,Gaëlle Pérot,Camille Dupin,Agnès Daubech,Genevieve Belleannée,Audrey Gros,Antoine Italiano,Isabelle Soubeyran +11 more
Journal ArticleDOI
YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas.
Zofia Hélias-Rodzewicz,Gaëlle Pérot,Gaëlle Pérot,Frédéric Chibon,Céline Ferreira,Céline Ferreira,Pauline Lagarde,Philippe Terrier,Jean-Michel Coindre,Alain Aurias,Alain Aurias +10 more
TL;DR: Data suggest that genetics events could be involved in oncogenesis and progression of soft tissue sarcomas, and Welch test analyses of transcriptome data demonstrate that tumors with amplicons share a large set of upregulated and downregulated genes.