Agnès Leroux

TL;DR: A prognostic gene expression signature, complexity index in sarcomas (CINSARC), composed of 67 genes related to mitosis and chromosome management, is established, which predicts metastasis outcome and predicts outcome for gastrointestinal stromal tumors, breast carcinomas and lymphomas.

TL;DR: The 12q13‐15 amplicon which contains MDM2 and CDK4 in well‐differentiated and dedifferentiated liposarcomas (WDLPS/DDLPS) was investigated using fluorescence in situ hybridization analysis and found a frequent amplification and overexpression of YEATS4, an oncogene that inactivates P53, suggesting that YEATs4 might play an important role together with MDM 2 in WDL PS/DD

TL;DR: Wild-type β-catenin seems to be an interesting prognostic marker that might be useful in the therapeutic management of extra-abdominal fibromatosis from a large multicentric retrospective study.

TL;DR: It is found that MDM2+/CDK4- WDLPS/DDLPS represent a distinct clinical subgroup with favorable prognostic features, including low-grade lipoma-like histology, peripheral location, and lower rate of recurrence.

TL;DR: A nonrandom occurrence of trisomy 8 associated with an increased risk of recurrence is revealed and Alterations of APC, including loss of the entire locus, and CTNNB1 mutation could explain the tumorigenesis in 89% of sporadic desmoid tumors and desmoids tumors occurring in the context of Gardner's syndrome.