G
Gail E. Louw
Researcher at University of Cape Town
Publications - 11
Citations - 1144
Gail E. Louw is an academic researcher from University of Cape Town. The author has contributed to research in topics: Drug resistance & Mycobacterium tuberculosis. The author has an hindex of 10, co-authored 11 publications receiving 1007 citations. Previous affiliations of Gail E. Louw include Stellenbosch University.
Papers
More filters
Journal ArticleDOI
Drug resistance in Mycobacterium tuberculosis.
Rabia Johnson,Elizabeth M. Streicher,Gail E. Louw,Robin M. Warren,Paul D. van Helden,Thomas C. Victor +5 more
TL;DR: Recommendations for Tuberculosis treatment according to the WHO guidelines, the drug resistance problem in the world, mechanisms of resistance to first line and second line drugs and applications of molecular methods to detect resistance causing gene mutations are described.
Journal ArticleDOI
A balancing act: efflux/influx in mycobacterial drug resistance.
Gail E. Louw,Robin M. Warren,N. C. Gey van Pittius,Christopher R.E. McEvoy,P. D. van Helden,Tommie C. Victor +5 more
TL;DR: The tubercle bacillus has become a central player in the epidemiology of diarrheal disease and its role in this disease has become increasingly important in the management of infectious disease outbreaks.
Journal ArticleDOI
Rifampicin Reduces Susceptibility to Ofloxacin in Rifampicin-resistant Mycobacterium tuberculosis through Efflux
Gail E. Louw,Robin M. Warren,Nicolaas C. Gey van Pittius,Rosalba Leon,Adelina Jimenez,Rogelio Hernández-Pando,Christopher R.E. McEvoy,Melanie Grobbelaar,Megan Murray,Paul D. van Helden,Thomas C. Victor +10 more
TL;DR: Exposure of rifampicin resistant M. tuberculosis strains to rifampsicin can potentially compromise the efficacy of the second-line treatment regimens containing ofloxacin, thereby emphasising the need for rapid diagnostics to guide treatment.
Journal ArticleDOI
Efflux pump inhibitors: targeting mycobacterial efflux systems to enhance TB therapy.
Caroline M. Pule,Samantha L. Sampson,Robin M. Warren,P. A. Black,Paul D. van Helden,Tommie C. Victor,Gail E. Louw +6 more
TL;DR: The current efflux pump inhibitors effective against M. tuberculosis, the effect of efflux Pump inhibitors on mycobacterial growth and the clinical promise of treatment with efflux pumps inhibitors and standard anti-TB therapy are highlighted.
Journal ArticleDOI
Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis
P. A. Black,Robin M. Warren,Gail E. Louw,Paul D. van Helden,Thomas C. Victor,Bavesh D. Kana,Bavesh D. Kana +6 more
TL;DR: Advances in the study of the mycobacterial ETC are detail, which suggests that energy metabolism and ATP production through the PMF, which is established by the electron transport chain (ETC), are critical in determining the drug susceptibility of M. tuberculosis.