G
Gan-Xin Yan
Researcher at Lankenau Institute for Medical Research
Publications - 115
Citations - 10902
Gan-Xin Yan is an academic researcher from Lankenau Institute for Medical Research. The author has contributed to research in topics: QT interval & Repolarization. The author has an hindex of 42, co-authored 105 publications receiving 10110 citations. Previous affiliations of Gan-Xin Yan include Case Western Reserve University & Xi'an Jiaotong University.
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Journal ArticleDOI
Is there a significant transmural gradient in repolarization time in the intact heart? Cellular basis of the T wave: a century of controversy.
Chinmay Patel,James F. Burke,Harsh Patel,Prasad Gupta,Peter R. Kowey,Charles Antzelevitch,Gan-Xin Yan +6 more
TL;DR: Since its initial invention, the body surface ECG has become a commonly used and extremely valuable test for the diagnosis of a variety of cardiac conditions and the cellular basis of ECG waveforms, particularly the T wave, remains a matter of debate.
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Role of signal-averaged electrocardiograms in arrhythmic risk stratification of patients with Brugada syndrome: a prospective study.
Zheng-rong Huang,Chinmay Patel,Weihua Li,Qiang Xie,Rong Wu,Lijuan Zhang,Rong Tang,Xiaoquen Wan,Yuxiao Ma,Wuyang Zhen,Lei Gao,Gan-Xin Yan,Gan-Xin Yan,Gan-Xin Yan +13 more
TL;DR: The results of this study support the role of LP detected by SAECG in arrhythmic risk stratification of Brugada syndrome patients.
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Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine
Lin Wu,Donglin Guo,Hong Li,James Hackett,Gan-Xin Yan,Zhen Jiao,Charles Antzelevitch,John C. Shryock,Luiz Belardinelli +8 more
TL;DR: Quinidine had biphasic proarrhythmic effects in the presence of ATX-II, suggesting that late I(Na) is a modulator of the arrhythmogenicity of quinidine.
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L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation.
TL;DR: The morphology of the mammalian cardiac action potential is an important factor in the susceptibility to drug‐induced early afterdepolarizations (EADs) that may initiate Torsade de Pointes (TdP).
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Mechanisms underlying arrhythmogenesis in long QT syndrome.
TL;DR: Evidence obtained from the studies using the rabbit left and right ventricular wedge preparations indicates that the development of TdP is relying not only on the genesis of an R-on-T trigger, but also on the formation of a functional reentrant substrate.