Showing papers in "Heart Rhythm in 2009"

TL;DR: Cleveland Clinic, Department of Cardiovascular Medicine, Cleveland, OH, Ohio State University, Division of ardiovascular Medicine, Columbus, Ohio, Broward General Medical Center, Fort Lauderdale, FL, University Hospital, ivision of cardiovascular medicine, Pisa, Italy, University of Miami, Cardiothoracic Surgery, Miami, FL as discussed by the authors, St. Thomas esearch Institute and Providence St. Joseph Medical enter, Burbank, CA, American Heart Association Representative.

TL;DR: Etienne M. Aliot, MD, FESC, FHRS, William G. Stevenson, this article, Frank Bogun, MD4, C. Neal Kay, MD12, Karl-Heinz Kuck, Dr.

TL;DR: Further efforts are needed to develop better techniques and tools to safely, effectively, and permanently isolate the PV antra, to identify which sites are critical to the maintence of AF, and to create durable transmural linear lesions to interrupt intraatrial reentry.

TL;DR: This cohort increases the publicly available compendium of putative LQTS-associated mutations by >50%, and approximately one-third of the most recently detected mutations continue to be novel.

TL;DR: The purpose of this study was to make recommendations based on the literature and on expert opinion regarding drug safety, and to ensure worldwide online and up-to-date availability of this information to all physicians who treat Brugada syndrome patients.

TL;DR: Radiofrequency ablation leading to elimination of LA-to-RA frequency gradients predicts long-term SR maintenance in AF patients.

TL;DR: Videoscopic denervation surgery, in addition to traditional LCSD, offers a safe and effective treatment option for the personalized medicine required for patients with LQTS/CPVT, and there has been a marked reduction in cardiac events.

TL;DR: This document is a consensus statement by the major American societies of physicians who work in the interventional laboratory environment affirm that the inter conventional laboratory poses workplace hazards that must be acknowledged, better understood, and mitigated to the greatest extent possible.

TL;DR: Pulmonary vein antrum isolation guided by intracardiac echocardiography results in significant freedom from atrial fibrillation, even when performed by multiple operators in different centers.

TL;DR: The hope is that as more is learned about the mechanisms of AF and with better preoperative diagnostic technologies capable of precisely locating the areas responsible for AF, it will become possible to tailor specific lesion sets and ablation modalities to individual patients, making the surgical treatment of AF available to a larger population of patients.

TL;DR: In this paper, the authors evaluated changes in miR-1 and Kir2 subunit expression in relation to I K1 alterations in patients with persistent atrial fibrillation.

TL;DR: In loss-of-function SCN5A channelopathies, patients carrying T and M(inactive) mutations develop a more severe phenotype than those with M( active) mutations, associated with more severe conduction disorders.

TL;DR: Selective GP ablation directed by high-frequency stimulation does not eliminate paroxysmal AF in the majority of patients, and an anatomic approach for regional ablation at the sites of GP confers better results.

TL;DR: The utility of fQRS in risk stratification of sudden cardiac death needs to be explored further, especially in nonischemic cardiomyopathy and heart failure.

TL;DR: In 63 patients with paroxysmal AF, GP ablation alone (before PV antrum isolation) significantly decreased the occurrence of PV firing and decreased the inducibility of sustained AF, and markedly reduced or eliminated the left atrial FAP areas.

TL;DR: The clinical profile of 108 newly diagnosed probands with suspected ARVC/D indicates that a combination of diagnostic tests is needed to evaluate the presence of right ventricular structural, functional, and electrical abnormalities.

TL;DR: Findings obtained in vitro suggest that electrotonic interactions following gap junctional coupling between myofibroblasts and cardiomyocytes in structurally remodeled fibrotic hearts might directly initiate the main mechanisms underlying arrhythmogenesis, that is, abnormal automaticity and abnormal impulse conduction.

TL;DR: In this article, the authors correlate delayed enhanced magnetic resonance imaging (DE-MRI) and electroanatomic (EA) mapping for the exact assessment of myocardial infarct scar.

TL;DR: In this paper, the authors evaluated the efficacy and safety of PVI under therapeutic international normalized ratio (INR) for 3,052 patients with therapeutic INR (≥1.8) at the time of ablation.

TL;DR: Catheter ablation of VT in patients with cardiac sarcoidosis refractory to medical therapy is effective in eliminating VT or markedly reducing the VT burden.

TL;DR: Fibroblasts affect cardiac conduction by acting as obstacles or by creating electrotonic loading and elevating myocyte resting potential, which may facilitate induction of reentry in cardiac tissue with fibrosis.

TL;DR: The hazard of Sprint Fidelis lead failure is increasing, whereas the failure rates of other defibrillator leads are low and stable, and Physicians should consider these data when managing patients who have Sprint FidelIS leads.

TL;DR: Patients show a variable yet predominantly cardiologic phenotype characterized by conduction disease at an early age and RV involvement including right bundle branch block and/or RV tachycardias and arrhythmogenic RV cardiomyopathy phenocopies, suggesting a localized effect of desmin on the structure of the cardiac intercalated disks might contribute to disease pathogenesis.

TL;DR: HCN4-/PAS-positive cardiomyocytes and CD117/c-kit-positive ICLC scattered among abundant inflammatory infiltrate, fibrous tissue, and sympathetic nerve structures in the atria and at the PV-LA junctions might be a substrate for the maintenance of chronic AF.

TL;DR: Conduction velocity and electrogram amplitude and degree of fractionation can be used to discriminate the nature of the substrate and characteristics of fibrosis, giving rise to slow conduction.

TL;DR: Post-infarction patients with frequent PVCs may have a reversible form of cardiomyopathy and DE-MRI may identify patients in whom the LVEF may improve after ablation of frequent PVCe, which was successful in 15 of 15 patients.

TL;DR: It is not the repolarization gradient but the restitution characteristics of the tissue with the shorter action potential, in combination with the time of arrival of the premature wavefront at the distal side of the line of block, that determines the occurrence of reentry.

TL;DR: Although a dangerous condition because of unreliable escape mechanism, proper diagnosis of paroxysmal AVB is often missed and overlooked because of its unfamiliarity, unpredictability, and in some cases, no clear evidence of atrioventricular conduction disease during normal 1:1 conduction.