Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives Xiaoqiang Chen, Tuhin Pradhan, Fang Wang, Jong Seung Kim,* and Juyoung Yoon* Departments of Chemistry and Nano Science and of Bioinspired Science (WCU), Ewha Womans University, Seoul 120-750, Korea State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China Department of Chemistry, Korea University, Seoul 136-701, Korea

Fluorescent chemosensors based on spiroring-opening of xanthenes and related derivatives.

This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.

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Chromone: A Valid Scaffold in Medicinal Chemistry

There is great need for stand-alone luminescence-based chemosensors that exemplify selectivity, sensitivity, and applicability and that overcome the challenges that arise from complex, real-world media. Discussed herein are recent developments toward these goals in the field of supramolecular luminescent chemosensors, including macrocycles, polymers, and nanomaterials. Specific focus is placed on the development of new macrocycle hosts since 2010, coupled with considerations of the underlying principles of supramolecular chemistry as well as analytes of interest and common luminophores. State-of-the-art developments in the fields of polymer and nanomaterial sensors are also examined, and some remaining unsolved challenges in the area of chemosensors are discussed.

/pdf/supramolecular-luminescent-sensors-1rs45r4um4.pdf

Supramolecular Luminescent Sensors

New Cu(II), Co(II), Ni(II) complexes with aroyl-hydrazone based ligand. Synthesis, spectroscopic characterization and in vitro antibacterial evaluation

Considerable amount of research has been carried out on designing and improving metal-recognition methodologies in environmental and biological media. The development of fluorescent-based techniques has proven to be an important milestone for non-invasive metal detection and quantification in a multichannel environment. Metals as natural components of the Earth's crust are generally present in trace concentrations in environmental samples, wherein humic substances have a complexation affinity toward them. Iron, zinc and copper are the 1st, 2nd and 3rd most abundant elements that are indispensable to the human body in trace amounts as they play crucial roles in many biological processes. However, unregulated amounts either an excess or deficiency may exacerbate deterioration of the vital organs and trigger the progression of complications. In addition to these three essential elements, mercury is widely considered to be one of the most hazardous pollutants and highly dangerous elements due to its recognized accumulative and toxic effects in the environment and in biological media. In the present study, we attempted to summarize all the recently developed fluorescent signaling materials for the detection of Cu2+, Fe2+/Fe3+, Zn2+ and Hg2+. The spectral shifts in the molecules on metal chelation, the mode of complexation and the stoichiometries of the resulting adducts have been discussed in detail. Furthermore, we highlight molecules that have been reported as an intracellular metal detector via bioimaging, which can be useful for the future design and development of cell-viable and membrane-permeable molecular probes.

Optical sensor: a promising strategy for environmental and biomedical monitoring of ionic species

A novel fluorescein derivative as a colorimetric chemosensor for detecting copper(II) ion

Synthesis, crystal structure, antioxidant activities and DNA-binding studies of the Ln(III) complexes with 7-methoxychromone-3-carbaldehyde-(4'-hydroxy) benzoyl hydrazone.

The neutral mononuclear Ln(III) complexes (Ln = La, Sm) with 7-methoxychrom-one-3-carbaldehyde-isonicotinoyl hydrazone ligand (L) have been synthesized, characterized and investigated their interactions with calf-thymus DNA. The results show that the binding affinity of the La(III) complex is stronger than that of the Sm(III) complex and that of the ligand (L). Furthermore, the antioxidant activities of the ligand (L) and its Ln(III) complexes (Ln = La, Sm) were studied in detail.

Crystal structures, DNA-binding studies and antioxidant activities of the Ln(III) complexes with 7-methoxychromone-3-carbaldehyde-isonicotinoyl hydrazone

Synthesis, fluorescence study and biological evaluation of three Zn(II) complexes with Paeonol Schiff base.

Water-soluble Ni(II) and Cu(II) complexes of a flexible Schiff-base ligand have been synthesized, and the Ni(II) complex was characterized by X-ray crystallography The interactions of the two complexes with calf thymus DNA were investigated by spectroscopic and viscosity measurements in water The results suggest that the two complexes bind to DNA within the groove Antioxidant experiments against OH• and O
 2
 −•
 show that these two complexes have excellent ability to scavenge O
 2
 −•
 , and the Cu(II) complex exhibits better activity than the Ni(II) complex

Gao-Fei Qi

Papers

A novel fluorescein derivative as a colorimetric chemosensor for detecting copper(II) ion

Synthesis, crystal structure, antioxidant activities and DNA-binding studies of the Ln(III) complexes with 7-methoxychromone-3-carbaldehyde-(4'-hydroxy) benzoyl hydrazone.

Crystal structures, DNA-binding studies and antioxidant activities of the Ln(III) complexes with 7-methoxychromone-3-carbaldehyde-isonicotinoyl hydrazone

Synthesis, fluorescence study and biological evaluation of three Zn(II) complexes with Paeonol Schiff base.

Crystal structure and biological activities of water-soluble nickel(II) and copper(II) complexes of a Schiff-base derived from paeonol