Gao Li

TL;DR: Four new diarylheptanoids (1-4), along with two known tetralones (5, 6) were isolated from the roots of Juglans mandshurica and their structures were elucidated on the basis of spectroscopic studies.

TL;DR: LJE significantly suppressed the increased activity of XO and type conversion of the xanthine dehydrogenase to XO in diabetic rat liver, suggesting that LJE would be of great value in preventing hyperglycemia in diabetes mellitus as a dietary supplement possibly, through its antioxidant activity.

TL;DR: Activity-guided fractionation based on topoisomerase I inhibitory activity lead to the isolation of ten lignans from the methylene chloride extract of the bark of Machilus thunbergii SIEB, and all of these compounds exhibited weak or no cytotoxicities against either the human colon carcinoma cell line (HT-29) or the human breast carcinomacell line (MCF-7).

TL;DR: The bioassay-guided fractionation of the methylene chloride soluble portion of a methanol extract of Machilus thunbergii bark led to the isolation of four known lignans, machilin A, meso-monomethyl dihydroguaiaretic acid, nectandrin A and nect andrin B, which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells.

TL;DR: The inhibitory effects of these compounds, isolated from the roots of Juglans mandshurica Maxi-mowicz, are reported, on the DNA topoisomerases I and II activities, of all these compounds.