G
Gareth Bowen
Publications - 2
Citations - 661
Gareth Bowen is an academic researcher. The author has contributed to research in topics: Mycobacterium vaccae & Eosinophilia. The author has an hindex of 2, co-authored 2 publications receiving 654 citations.
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Journal ArticleDOI
Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells.
Claudia Zuany-Amorim,Elzbieta Sawicka,Elzbieta Sawicka,C. Manlius,Alain Le Moine,Laura Rosa Brunet,David M. Kemeny,Gareth Bowen,Graham A. W. Rook,Christoph Walker +9 more
TL;DR: Treatment of mice with SRP299, a killed Mycobacterium vaccae-suspension gives rise to allergen-specific CD4+CD45RBLo regulatory T cells, which confer protection against airway inflammation and may have an essential role in restoring the balance of the immune system to prevent and treat allergic diseases.
Journal ArticleDOI
Long-term protective and antigen-specific effect of heat-killed Mycobacterium vaccae in a murine model of allergic pulmonary inflammation.
Claudia Zuany-Amorim,C. Manlius,Alexandre Trifilieff,Laura Rosa Brunet,Graham A. W. Rook,Gareth Bowen,Graham F. Pay,Christoph Walker +7 more
TL;DR: Results clearly demonstrate that M. vaccae is effective in blocking allergic inflammation by a mechanism independent of IFN-γ, induces long term and Ag-specific protection, and therefore has both prophylactic and therapeutic potential for the treatment of allergic diseases.