Graham A. W. Rook

TL;DR: Real-time reverse transcription PCR is used to assess the levels of 13 housekeeping genes expressed in peripheral blood mononuclear cell culture and whole blood from healthy individuals and those with tuberculosis and shows that RNA specifying human acidic ribosomal protein was the most suitable housekeeping gene for normalizing mRNA levels in human pulmonary tuberculosis.

TL;DR: This report demonstrates that experimental results are highly dependent on the reference gene chosen, and normalized sets of data with convention-ally used reference genes, including conventionally chosen genes to address the impact of a validation exercise on intergroup comparisons.

TL;DR: Treatment of mice with SRP299, a killed Mycobacterium vaccae-suspension gives rise to allergen-specific CD4+CD45RBLo regulatory T cells, which confer protection against airway inflammation and may have an essential role in restoring the balance of the immune system to prevent and treat allergic diseases.

TL;DR: It is suggested that the requirement for microbial input from the environment to drive immunoregulation is a major component of the beneficial effect of green space, and a neglected ecosystem service that is essential for the authors' well-being.

TL;DR: Findings help to explain claims for the efficacy of vitamin D in the treatment of some forms of tuberculosis, and also the occasional finding of raised serum calcium, and disturbed vitamin D metabolism in these patients.