G
Gary A. Meints
Researcher at University of Illinois at Urbana–Champaign
Publications - 8
Citations - 743
Gary A. Meints is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Farnesyl diphosphate synthase & Farnesyl pyrophosphate. The author has an hindex of 7, co-authored 7 publications receiving 728 citations. Previous affiliations of Gary A. Meints include University of London.
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Journal ArticleDOI
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Subhash Ghosh,Julian M. W. Chan,Christopher R. Lea,Gary A. Meints,Jared C. Lewis,Zev Tovian,Ryan M. Flessner,Timothy C. Loftus,Iris Bruchhaus,Howard Kendrick,Simon L. Croft,Robert G. Kemp,Seike Kobayashi,Tomoyoshi Nozaki,Eric Oldfield +14 more
TL;DR: Results show that bisphosphonates appear to be useful lead compounds for the development of novel antiamebic and antimalarial drugs.
Journal ArticleDOI
Quantitative Structure-Activity Relationships for γδ T Cell Activation by Bisphosphonates
John M. Sanders,Subhash Ghosh,Julian M. W. Chan,Gary A. Meints,Hong Wang,Amy M. Raker,Yongcheng Song,Alison Colantino,Agnieszka Burzynska,Paweł Kafarski,Craig T. Morita,Eric Oldfield +11 more
TL;DR: The activation of γ δ T cells by a broad range of bisphosphonates is reported and a pharmacophore model for γδ T cell activation is developed and a comparative molecular similarity index analysis (CoMSIA) approach is used to make quantitative relationships between γ ΔT cell activation by bisph phosphonates and their three-dimensional structures.
Journal ArticleDOI
3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.
John M. Sanders,Aurora Ortiz Gomez,Junhong Mao,Gary A. Meints,Erin M. Van Brussel,Agnieszka Burzynska,Paweł Kafarski,Dolores González-Pacanowska,Eric Oldfield +8 more
TL;DR: The results are of general interest since they represent the first detailed quantitative structure-activity relationship study of the inhibition of an expressed farnesyl pyrophosphate synthase enzyme by bisphosphonate inhibitors and that the activity of these inhibitors can be predicted within about a factor of 3 by using 3D-QSAR techniques.
Journal ArticleDOI
Activity of Bisphosphonates against Trypanosoma brucei rhodesiense
Michael B. Martin,John M. Sanders,Howard Kendrick,Kate de Luca-Fradley,Jared C. Lewis,Joshua S. Grimley,Erin M. Van Brussel,Jeffrey R. Olsen,Gary A. Meints,Agnieszka Burzynska,Paweł Kafarski,Simon L. Croft,Eric Oldfield +12 more
TL;DR: Several bisphosphonates were found to have large therapeutic indices (> or =200:1) as well as low IC(50) values, suggesting their further investigation as antiparasitic agents against T. b.
Journal ArticleDOI
Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.
Junhong Mao,Sujoy Mukherjee,Yong Zhang,Rong Cao,John M. Sanders,Yongcheng Song,Yonghui Zhang,Gary A. Meints,Yi Gui Gao,Dushyant Mukkamala,Michael P. Hudock,Eric Oldfield +11 more
TL;DR: X-ray crystallography is used to determine the structures of two potent bisphosphonate inhibitors, finding good agreement with the computational results, opening up the possibility of using the combination of NMR, quantum chemistry and molecular docking to facilitate the design of other, novel prenytransferase inhibitors.