G
Gary H. Gibbons
Researcher at National Institutes of Health
Publications - 114
Citations - 5958
Gary H. Gibbons is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Population & Adiponectin. The author has an hindex of 37, co-authored 113 publications receiving 5532 citations. Previous affiliations of Gary H. Gibbons include Morehouse School of Medicine.
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A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo.
Ryuichi Morishita,Gary H. Gibbons,M. Horiuchi,Kristin E. Ellison,M Nakama,Lunan Zhang,Yasufumi Kaneda,Toshio Ogihara,Victor J. Dzau +8 more
TL;DR: Transfection with E2F decoy inhibited expression of c-myc, cdc2, and the PCNA gene as well as vascular smooth muscle cell proliferation both in vitro and in the in vivo model of rat carotid injury.
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Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia
Ryuichi Morishita,Gary H. Gibbons,Kristin E. Ellison,Masatoshi Nakajima,Lunan Zhang,Yasufumi Kaneda,Toshio Ogihara,Victor J. Dzau +7 more
TL;DR: It is documents that a single intraluminal molecular delivery of combined cdc2 kinase and PCNA antisense ODNs results in a sustained inhibition of neointima formation in the rat carotid balloon-injury model.
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Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium.
TL;DR: In this article, the effect of shear stress on the expression of the heparin-binding growth factors platelet-derived growth factor B chain (PDGF-B) and basic fibroblast growth factor (bFGF) in bovine aortic endothelial cells using a purpose-built cone-plate viscometer was explored.
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Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides.
Ryuichi Morishita,Gary H. Gibbons,Kristin E. Ellison,Masatoshi Nakajima,H. E. Von Der Leyen,Lunan Zhang,Yasufumi Kaneda,Toshio Ogihara,Victor J. Dzau +8 more
TL;DR: Results demonstrate that a single intraluminal administration of antisense ODN directed to cell cycle regulatory genes (e.g., cdk 2 kinase) using the HVJ method can result in a sustained inhibition of neointima formation after balloon angioplasty in rat carotid injury model.
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Predictive Value of Reactive Hyperemia for Cardiovascular Events in Patients With Peripheral Arterial Disease Undergoing Vascular Surgery
Alex L. Huang,Annemarie E. Silver,Elena Shvenke,David W. Schopfer,Eiman Jahangir,Megan Titas,Alex Shpilman,James O. Menzoian,Michael T. Watkins,Joseph D. Raffetto,Gary H. Gibbons,Jonathan Woodson,Palma Shaw,Mandeep Dhadly,Robert T. Eberhardt,John F. Keaney,Noyan Gokce,Joseph A. Vita +17 more
TL;DR: Lower reactive hyperemia is associated with increased cardiovascular risk in patients with peripheral arterial disease and flow-mediated dilation incrementally relate to cardiovascular risk, although impaired flow- mediated dilation was the stronger predictor in this population.