Gary K. Grunwald

TL;DR: Among a cohort of men in the VA health care system who underwent coronary angiography and had a low serum testosterone level, the use of testosterone therapy was associated with increased risk of adverse outcomes, and these findings may inform the discussion about the potential risks ofosterone therapy.

TL;DR: A reduction in dietary fat without intentional restriction of energy intake causes weight loss, which is more substantial in heavier subjects.

TL;DR: A retrospective cohort study of all US veterans undergoing elective coronary angiography for CAD between October 2007 and September 2012 found that there was no significant association between 1- or 2-vessel nonobstructive CAD and mortality, but there were significant associations with mortality for 3-vessels nonobStructive CAD.

Abstract: We consider the kernel estimator of conditional density and derive its asymptotic bias, variance, and mean-square error. Optimal bandwidths (with respect to integrated mean-square error) are found and it is shown that the convergence rate of the density estimator is order n –2/3. We also note that the conditional mean function obtained from the estimator is equivalent to a kernel smoother. Given the undesirable bias properties of kernel smoothers, we seek a modified conditional density estimator that has mean equivalent to some other nonparametric regression smoother with better bias properties. It is also shown that our modified estimator has smaller mean square error than the standard estimator in some commonly occurring situations. Finally, three graphical methods for visualizing conditional density estimators are discussed and applied to a data set consisting of maximum daily temperatures in Melbourne, Australia.

TL;DR: Simvastatin lowers hsCRP by 14 days, independent of its effect on LDL cholesterol, which has potential implications in the management of acute coronary syndromes.