G
Gary L. Westbrook
Researcher at Oregon Health & Science University
Publications - 129
Citations - 23610
Gary L. Westbrook is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: NMDA receptor & Excitatory postsynaptic potential. The author has an hindex of 64, co-authored 126 publications receiving 22934 citations. Previous affiliations of Gary L. Westbrook include Vollum Institute & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.
TL;DR: Using voltage-clamp experiments on mouse spinal cord neurones, it is shown that the voltage-sensitivity of NMDA action is greatly reduced on the withdrawal of physiological concentrations (∼1 mM) of Mg2+ from the extracellular fluid, providing further evidence that Mg 2+ blocks inward current flow through ion channels linked to NMDA receptors.
Journal ArticleDOI
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
Amy B. MacDermott,Amy B. MacDermott,Mark L. Mayer,Gary L. Westbrook,Stephen J. Smith,Jeffery L. Barker +5 more
TL;DR: It is directly demonstrated that excitatory amino acids acting at NMDA receptors on spinal cord neurones increase the intracellular Ca2+ activity, measured using the indicator dye arsenazo III, and that this is the result of Ca2- influx through NMDA receptor channels.
Journal ArticleDOI
The physiology of excitatory amino acids in the vertebrate central nervous system.
Mark L. Mayer,Gary L. Westbrook +1 more
TL;DR: In this article, the authors propose a method to solve the problem of unstructured data.Abbreviations 198 and 198.3.1.5.1].
Journal ArticleDOI
The time course of glutamate in the synaptic cleft.
TL;DR: The time course of free glutamate predicts that dissociation contributes to the decay of the AMPA receptor-mediated postsynaptic current.
Journal ArticleDOI
Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones.
Mark L. Mayer,Gary L. Westbrook +1 more
TL;DR: Manganese both permeates and blocks the NMDA receptor channel, implying an apparent increase in PCa/PNa on lowering [Na+]o and may result from interaction of permeant ions within the channel.