Gary Larson

TL;DR: Using pharmacokinetic and pharmacodynamic data, it is shown that maintaining adequate MEK inhibition throughout the dosing interval is likely more important than achieving high peak levels because greater efficacy was achieved with more frequent but lower dosing.

TL;DR: From chemical compound library screening using an HCV NS5B RNA-dependent RNA polymerase enzymatic assay, a substituted quinoxaline hit with an IC(50) of 5.5 microM was identified and a series of substituted quInoxaline amide derivatives were synthesized based on the hit's pharmacophore, and a good structure-activity relationship was observed.

TL;DR: The results underscore the specificity of VRX0466617 for Chk2, both in vitro and in vivo, and support the use of this compound as a biological probe to study the Chk 2-dependent pathways.

TL;DR: The results suggest that the major mechanism of mitotic arrest at the lowest effective concentrations of 2ME2 is suppression of microtubule dynamics rather than microtubules depolymerization per se.

TL;DR: De novo RNA synthesis by hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase has been investigated using short RNA templates and it was discovered that the secondary structure of a template was not essential for de novo initiation and that 3′-terminal bases of a templates conferred specificity in selection of an initiation site.