Gary M. Jones

TL;DR: It is suggested that active CTL selection of viral variants could contribute to the pathogenesis of AIDS and that clinical progression can occur despite high levels of circulating HIV-1-specific CTLs.

TL;DR: In this article, the authors compared 10 lines of skin fibroblasts from individuals with genetic disorders predisposing to a high risk of cancer with nine lines from normal adult donors with respect to chromatid damage after x-irradiation.

TL;DR: This response in skin fibroblasts from individuals with genetic conditions predisposing to cancer than in comparable cells from clinically normal controls could provide the basis of a test for detecting individuals carrying genes that predispose to a high risk of cancer.

TL;DR: The persistence of chromatid breaks and gaps in lymphocytes following radiation-induced DNA damage during G2 suggests a deficiency or deficiencies in DNA repair that may be the defect at the molecular level that results in the enhanced radiosensitivity and cancer proneness characterizing A-T gene carriers and patients.

TL;DR: Most of the chromosomal abnormalities observed in long-term culture of mouse cells may result from exposure of cells or medium to fluorescent room lights in the presence of atmospheric oxygen, and can be minimized by shielding cells and medium from light, lowering the PO2 of the medium, and including reducing agents such as glutathione and ascorbic acid in the medium formulation.