G
Gary Yellen
Researcher at Harvard University
Publications - 113
Citations - 15373
Gary Yellen is an academic researcher from Harvard University. The author has contributed to research in topics: Gating & Ion channel. The author has an hindex of 54, co-authored 109 publications receiving 14109 citations. Previous affiliations of Gary Yellen include Yale University & Johns Hopkins University.
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Journal ArticleDOI
The inward rectification mechanism of the HERG cardiac potassium channel
TL;DR: The characteristics of this gating suggest a specific role for this channel in the normal suppression of arrhythmias, and the inactivation gating mechanism resembles that of C-type inactivation of K+ channels.
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The voltage-gated potassium channels and their relatives
TL;DR: The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins with pores that pass millions of ions per second across the membrane with astonishing selectivity.
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Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel.
TL;DR: Findings suggest that an amino acid residue that specifically affects the affinity for intracellular TEA has now been identified by site-directed mutagenesis and suggest that this conserved region is intimately involved in the formation of the ion conduction pore of voltage-activated potassium channels.
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Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels.
Roderick MacKinnon,Gary Yellen +1 more
TL;DR: Specific amino acid residues have now been identified that affect channel blockade by the small ion tetraethylammonium, as well as the conduction of ions through the pore of the transiently voltage-activated Shaker H4 potassium channel.
Journal ArticleDOI
Gated Access to the Pore of a Voltage-Dependent K+ Channel
TL;DR: The results suggest that these channels open and close by the movement of an intracellular gate, distinct from the selectivity filter, that regulates access to the pore.