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Gaurav Bhatia
Researcher at Harvard University
Publications - 92
Citations - 23900
Gaurav Bhatia is an academic researcher from Harvard University. The author has contributed to research in topics: Controller (computing) & Population. The author has an hindex of 35, co-authored 88 publications receiving 16846 citations. Previous affiliations of Gaurav Bhatia include Delphi Automotive & Mercer University.
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Journal ArticleDOI
Estimating and interpreting FST: The impact of rare variants
Gaurav Bhatia,Gaurav Bhatia,Nick Patterson,Sriram Sankararaman,Sriram Sankararaman,Alkes L. Price,Alkes L. Price +6 more
TL;DR: Three specific issues related to estimating FST for a single SNP, combining estimates of FST across multiple SNPs, and selecting the set of SNPs used in the computation are clarified and proposed.
Journal ArticleDOI
Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis
Po-Ru Loh,Po-Ru Loh,Gaurav Bhatia,Gaurav Bhatia,Alexander Gusev,Alexander Gusev,Hilary K. Finucane,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,Samuela Pollack,Samuela Pollack,Teresa R de Candia,Sang Hong Lee,Sang Hong Lee,Naomi R. Wray,Kenneth S. Kendler,Michael Conlon O'Donovan,Benjamin M. Neale,Benjamin M. Neale,Nick Patterson,Alkes L. Price,Alkes L. Price +21 more
TL;DR: A fast algorithm for multicomponent, multi-trait variance-components analysis that overcomes prior computational barriers that made such analyses intractable at this scale is developed.
Journal ArticleDOI
Using Extended Genealogy to Estimate Components of Heritability for 23 Quantitative and Dichotomous Traits
Noah Zaitlen,Peter Kraft,Peter Kraft,Nick Patterson,Bogdan Pasaniuc,Gaurav Bhatia,Gaurav Bhatia,Samuela Pollack,Samuela Pollack,Alkes L. Price,Alkes L. Price +10 more
TL;DR: In this article, the authors examine phenotypic correlations across a range of relationships, from siblings to first cousins, and find that the excess phenotype correlation in these related individuals is predominantly due to shared environment as opposed to dominance or epistasis.
Journal ArticleDOI
Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia
Kevin Galinsky,Kevin Galinsky,Gaurav Bhatia,Po-Ru Loh,Po-Ru Loh,Stoyan Georgiev,Sayan Mukherjee,Nick Patterson,Alkes L. Price,Alkes L. Price +9 more
TL;DR: The FastPCA software is developed, which employs recent advances in random matrix theory to accurately approximate top PCs while reducing time and memory cost from quadratic to linear in the number of individuals, a computational improvement of many orders of magnitude.
Posted ContentDOI
Leveraging polygenic functional enrichment to improve GWAS power
Gleb Kichaev,Gaurav Bhatia,Po-Ru Loh,Steven Gazal,Kathryn S. Burch,Malika K. Freund,Armin P. Schoech,Bogdan Pasaniuc,Alkes L. Price +8 more
TL;DR: A method that leverages polygenic functional enrichment to incorporate coding, conserved, regulatory and LD-related genomic annotations into association analyses robustly increases GWAS power is introduced.