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Gavin McLaughlin
Researcher at Athlone Institute of Technology
Publications - 16
Citations - 231
Gavin McLaughlin is an academic researcher from Athlone Institute of Technology. The author has contributed to research in topics: Monoamine transporter & Monoamine neurotransmitter. The author has an hindex of 10, co-authored 16 publications receiving 191 citations. Previous affiliations of Gavin McLaughlin include Trinity College, Dublin.
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Journal ArticleDOI
Test purchase, synthesis, and characterization of 2-methoxydiphenidine (MXP) and differentiation from its meta- and para-substituted isomers
Gavin McLaughlin,Noreen Morris,Pierce V. Kavanagh,John D. Power,John E. O'Brien,Brian Talbot,Simon P. Elliott,Jason Wallach,Khoa Hoang,Hamilton Morris,Simon D. Brandt +10 more
TL;DR: Analytical data obtained for the three purchased samples were consistent with the synthesized 2-MXP standard and the differentiation between the isomers was possible, and distinct stability differences were observed for all three isomers during in-source collision-induced dissociation of the protonated molecule.
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Preparation and characterization of the ‘research chemical’ diphenidine, its pyrrolidine analogue, and their 2,2‐diphenylethyl isomers
Jason Wallach,Pierce V. Kavanagh,Gavin McLaughlin,Noreen Morris,John D. Power,Simon P. Elliott,Marion S. Mercier,David Lodge,Hamilton Morris,Nicola M. Dempster,Simon D. Brandt +10 more
TL;DR: 1,2- diphenylethylamines appears to reflect the exploration of alternatives to arylcyclohexylamine-type substances, such as methoxetamine, PCP and PCPy-based analogues that also show NMDA receptor activity as demonstrated here for diphenidine.
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Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family.
Felix P. Mayer,Nadine V. Burchardt,Ann M. Decker,John S. Partilla,Yang Li,Gavin McLaughlin,Pierce V. Kavanagh,Walter Sandtner,Bruce E. Blough,Simon D. Brandt,Michael H. Baumann,Harald H. Sitte +11 more
TL;DR: This study reports for the first time the mode of action for 2-, 3- and 4-FPM and identifies these NPS as monoamine releasers with marked potency at catecholamine transporters implicated in abuse and addiction.
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Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone
Gavin McLaughlin,Noreen Morris,Pierce V. Kavanagh,John D. Power,Geraldine Dowling,Brendan Twamley,John E. O'Brien,Brian Talbot,Donna Walther,John S. Partilla,Michael H. Baumann,Simon D. Brandt +11 more
TL;DR: The isomer N-methoxymephedrone was found to be a weak uptake blocker at DAT, NET and SERT, as well as a fully efficacious substrate-type releasing agent across all three transporters with EC50 values in the low micromolar range.
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The synthesis and characterization of the ‘research chemical’ N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide (3,5-AB-CHMFUPPYCA) and differentiation from its 5,3-regioisomer
Gavin McLaughlin,Noreen Morris,Pierce V. Kavanagh,John D. Power,Brendan Twamley,John E. O'Brien,Brian Talbot,Geraldine Dowling,Simon D. Brandt +8 more
TL;DR: The pyrazole core indicates a bioisosteric replacement of an indazole ring that is frequently associated with synthetic cannabinoids of the PINACA, FUBINACA, and CHMINACA series and both isomers were synthesized using two specific routes which supported the correct identification of the 'research chemical' as 3,5-AB-CHMFUPPYCA.