G
Gayathri Srinivasan
Researcher at Ohio State University
Publications - 5
Citations - 631
Gayathri Srinivasan is an academic researcher from Ohio State University. The author has contributed to research in topics: Transfer RNA & Translation (biology). The author has an hindex of 4, co-authored 5 publications receiving 597 citations. Previous affiliations of Gayathri Srinivasan include Massachusetts Institute of Technology.
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Pyrrolysine encoded by UAG in Archaea: charging of a UAG-decoding specialized tRNA.
TL;DR: Results indicate that pyrrolysine is the 22nd genetically encoded natural amino acid to be encoded by the UAG codon in methylamine methyltransferase genes of Methanosarcina barkeri.
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Identification and characterization of a tRNA decoding the rare AUA codon in Haloarcula marismortui.
Caroline Köhrer,Gayathri Srinivasan,Debabrata Mandal,Bibekanand Mallick,Zhumur Ghosh,Jayprokas Chakrabarti,Uttam L. RajBhandary +6 more
TL;DR: It is shown that a tRNA, currently annotated as elongator methionine tRNA and containing CAU as the anticodon, is aminoacylated with isoleucine in vivo and that this tRNA represents the missing isoleUCine tRNAs.
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Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp.
Anirban Mahapatra,Gayathri Srinivasan,Kerstin B. Richter,Andrew Meyer,Tanja Lienard,Jun Kai Zhang,Gang Zhao,Patrick T. Kang,Michael Chan,Gerhard Gottschalk,William W. Metcalf,Joseph A. Krzycki +11 more
TL;DR: The results support an association of LysRS1 with growth on methylamine, but not an essential role for Lys RS1/LysRS2 in the genetic encoding of pyrrolysine, however, decreased lysyl‐tRNALys in the lysS mutant provides a possible rationale for stable transfer of the bacterial lYSS gene to methanoarchaea.
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Translation initiation with GUC codon in the archaeon Halobacterium salinarum: implications for translation of leaderless mRNA and strict correlation between translation initiation and presence of mRNA.
TL;DR: GUC can serve as an initiation codon in archaea and the stem‐loop structure in the bop mRNA is important for translation, suggesting either a strong coupling between translation and mRNA stability or strong transcriptional polarity in H. salinarum.
Translation of the amber codon in methylamine methyltransferase genes of a methanogenic archaeon
TL;DR: Members of the Methanosarcinaceae family can in addition to hydrogen/carbon dioxide utilize several methylated compounds and convert them to methane and appear to have a unique mechanism for amber codon readthrough.