G
Geeta Nair
Researcher at St. Jude Children's Research Hospital
Publications - 5
Citations - 235
Geeta Nair is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Protoporphyrin IX & Population. The author has an hindex of 4, co-authored 5 publications receiving 214 citations.
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Journal ArticleDOI
Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels
TL;DR: The results demonstrate that ABCG2 plays a role in regulating PPIX levels during erythroid differentiation and suggest a potential role for ABCG 2 as a genetic determinant in erythropoietic protoporphyria.
Journal ArticleDOI
Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors.
John C. Panetta,Mark N. Kirstein,Mark N. Kirstein,Amar Gajjar,Geeta Nair,Maryam Fouladi,Richard L. Heideman,Mark R. Wilkinson,Clinton F. Stewart,Clinton F. Stewart +9 more
TL;DR: Covariate analysis showed that increasing age and body surface area (BSA) were associated with a significant increases in TMZ CL, Vc, and Cmax (P<0.05), and that decreasing age was associated with significant decreases in TMZ and MTIC AUC.
Journal ArticleDOI
A mechanistic mathematical model of temozolomide myelosuppression in children with high-grade gliomas
John C. Panetta,Mark N. Kirstein,Mark N. Kirstein,Amar J. Gajjar,Geeta Nair,Maryam Fouladi,Clinton F. Stewart +6 more
TL;DR: A mechanistic mathematical model is developed that describes the progression of neutrophils from their production in the bone marrow to their release in the plasma and is able to explain the lag in ANC reduction following a dose of TMZ, the ANC nadir, and the 'rebound effect' observed where the ANC recovers to levels greater than that observed pre-TMZ dose.
Journal ArticleDOI
Development of a pharmacokinetic limited sampling model for temozolomide and its active metabolite MTIC
Mark N. Kirstein,Mark N. Kirstein,John C. Panetta,Amar Gajjar,Geeta Nair,Lisa C. Iacono,Burgess B. Freeman,Clinton F. Stewart +7 more
TL;DR: Using data derived from the population analysis, the sampling times for a limited sample pharmacokinetic model for temozolomide and MTIC in children are prior to the temozoomide dose, and 15 min, 1.25 h and 6 h after the dose.
maturation plays a role in decreasing cellular protoporphyrin IX levels Increased expression of the Abcg2 transporter during erythroid
TL;DR: This article discusses red cells, Hematopoiesis and Stem Cells, and Gene Expression, which can be found in the following Blood collections.