Gemma Bale

TL;DR: Near-infrared spectroscopy measurements of cytochrome-c-oxidase have the potential to yield crucial information about cerebral metabolism at the patient bedside and this signal continues to hold significant interest in the understanding of the human brain in health and disease.

TL;DR: It is shown with a feasibility study that the relationship between haemoglobin oxygenation changes and CCO oxidation changes during these desaturation events was significantly associated with a magnetic resonance spectroscopy (MRS)-measured biomarker of injury severity (r = 0.91).

TL;DR: There is a substantial literature of work on measures of CCO in animal and in vitro studies; however, this review focuses on translational studies as mentioned in this paper, where methodologies for obtaining NIRS measurements of cytochrome-coxidase in the clinic and review studies in neonates and adults.

TL;DR: It is suggested that simultaneous neuromonitoring of perfusion and metabolism could provide critical information regarding clinically significant hemodynamic events prior to the onset of brain injury.

TL;DR: Broadband NIRS has the potential to provide an early, cotside, non-invasive, clinically relevant metabolic marker of perinatal hypoxic-ischaemic injury and a strong relationship between cerebral metabolism and cerebral oxygenation was associated with unfavourable outcome.