Gen Kanayama

TL;DR: Findings are consistent with the hypothesis that in some patients with bipolar affective disorder, there may be a reduction of frontal cortical function which may be associated with affective as well as attentional processing deficits.

TL;DR: Preliminary findings suggest that testosterone gel may produce antidepressant effects in the large and probably underrecognized population of depressed men with low testosterone levels.

TL;DR: Long-term use of supraphysiologic doses of AAS may cause irreversible cardiovascular toxicity, especially atherosclerotic effects and cardiomyopathy, while in other organ systems, evidence of persistent toxicity is more modest, and interestingly, there is little evidence for an increased risk of prostate cancer.

TL;DR: Recent cannabis users displayed greater and more widespread brain activation than normal subjects when attempting to perform a spatial working memory task, which suggests that recent cannabis users may experience subtle neurophysiological deficits, and that they compensate for these deficits by “working harder”—calling upon additional brain regions to meet the demands of the task.

TL;DR: The accumulating human and animal evidence showing that AAS may cause a distinct dependence syndrome is reviewed, and standard diagnostic criteria for substance dependence must be adapted slightly for cumulatively acting drugs such as AAS.