G
Gene S. Tan
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 56
Citations - 5387
Gene S. Tan is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Hemagglutinin (influenza) & Virus. The author has an hindex of 36, co-authored 42 publications receiving 4530 citations. Previous affiliations of Gene S. Tan include Thomas Jefferson University & J. Craig Venter Institute.
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Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo
TL;DR: DiLillo et al. as mentioned in this paper showed that anti-stalk mAbs can mediate antibody-dependent cell cytotoxicity and require interactions with Fc receptors for their in vivo neutralizing activity.
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Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes
Taia T. Wang,Gene S. Tan,Rong Hai,Natalie Pica,Lily Ngai,Damian C. Ekiert,Ian A. Wilson,Adolfo García-Sastre,Thomas M. Moran,Peter Palese +9 more
TL;DR: A hemagglutinin subunit 2 protein (HA2)-based synthetic peptide vaccine that provides protection in mice against influenza viruses of the structurally divergent subtypes H3N2, H1N1, and H5N1 is described.
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Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins.
TL;DR: Three monoclonal antibodies have been identified that are broadly-neutralizing against H3 influenza viruses spanning 40 years, demonstrating that broad-spectrum humoral immunity to influenza viruses can be elicited in vivo.
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Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses
Natalie Pica,Rong Hai,Florian Krammer,Taia T. Wang,Jad Maamary,Dirk Eggink,Gene S. Tan,Jens Krause,Thomas M. Moran,Cheryl R. Stein,David B. Banach,Jens Wrammert,Robert B. Belshe,Adolfo García-Sastre,Peter Palese +14 more
TL;DR: It is shown that infection with the 2009 pandemic H1N1 virus elicited a boost in titer of virus-neutralizing antibodies directed against the hemagglutinin stalk, and that those antibodies could have contributed to the disappearance of existing seasonal H 1N1 influenza virus strains.
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Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes
Rong Hai,Florian Krammer,Gene S. Tan,Natalie Pica,Dirk Eggink,Jad Maamary,Irina Margine,Randy A. Albrecht,Peter Palese +8 more
TL;DR: These chimeric recombinant viruses possess growth properties similar to those of wild-type influenza viruses and can be used as reagents to measure domain-specific antibodies in virological and immunological assays.