J
Jens Wrammert
Researcher at Emory University
Publications - 112
Citations - 11614
Jens Wrammert is an academic researcher from Emory University. The author has contributed to research in topics: Antibody & Vaccination. The author has an hindex of 41, co-authored 93 publications receiving 9134 citations. Previous affiliations of Jens Wrammert include Indiana University & Yerkes National Primate Research Center.
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Journal ArticleDOI
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
Jens Wrammert,Kenneth J. Smith,Joseph I. Miller,William A. Langley,Kenneth E. Kokko,Christian P. Larsen,Nai-Ying Zheng,Israel Mays,Lori Garman,Christina Helms,Judith A. James,Judith A. James,Gillian M. Air,J. Donald Capra,J. Donald Capra,Rafi Ahmed,Patrick C. Wilson,Patrick C. Wilson +17 more
TL;DR: The panel of influenza-virus-specific human mAbs allowed us to address the issue of original antigenic sin (OAS): the phenomenon where the induced antibody shows higher affinity to a previously encountered influenza virus strain compared with the virus strain present in the vaccine.
Journal ArticleDOI
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
Jens Wrammert,Dimitrios G. Koutsonanos,Gui-Mei Li,Srilatha Edupuganti,Jianhua Sui,Michael Morrissey,Megan McCausland,Ioanna Skountzou,Mady Hornig,W. Ian Lipkin,Aneesh K. Mehta,Behzad Razavi,Carlos del Rio,Nai-Ying Zheng,Jane-Hwei Lee,Min Huang,Zahida Ali,Kaval Kaur,Sarah F. Andrews,Rama Rao Amara,Youliang Wang,Suman R. Das,Christopher D. O'Donnell,J W Yewdell,Kanta Subbarao,Wayne A. Marasco,Mark J. Mulligan,Richard W. Compans,Rafi Ahmed,Patrick C. Wilson +29 more
TL;DR: Although scarce after annual influenza vaccination, B cells producing antibodies capable of neutralizing multiple influenza strains are abundant in humans infected with pandemic 2009 H1N1 influenza.
Journal ArticleDOI
Systems biology of vaccination for seasonal influenza in humans
Helder I. Nakaya,Jens Wrammert,Eva K. Lee,Luigi Racioppi,Luigi Racioppi,Stephanie Marie-Kunze,Stephanie Marie-Kunze,W. Nicholas Haining,Anthony R. Means,Sudhir Pai Kasturi,Sudhir Pai Kasturi,Nooruddin Khan,Nooruddin Khan,Gui-Mei Li,Megan McCausland,Vibhu Kanchan,Kenneth E. Kokko,Shuzhao Li,Shuzhao Li,Rivka Elbein,Aneesh K. Mehta,Alan Aderem,Kanta Subbarao,Rafi Ahmed,Bali Pulendran,Bali Pulendran +25 more
TL;DR: Systems approaches can be used to predict immunogenicity and provide new mechanistic insights about vaccines as well as demonstrate an unappreciated role for CaMKIV in the regulation of antibody responses.
Journal ArticleDOI
Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus
Lalita Priyamvada,Kendra M. Quicke,William H. Hudson,Nattawat Onlamoon,Jaturong Sewatanon,Srilatha Edupuganti,Kovit Pattanapanyasat,Kulkanya Chokephaibulkit,Mark J. Mulligan,Patrick C. Wilson,Rafi Ahmed,Mehul S. Suthar,Jens Wrammert +12 more
TL;DR: It is shown that both acute and convalescent dengue sera potently bind and neutralize ZIKV and that this cross-reactivity is also evident at the monoclonal level, suggesting that preexisting immunity to DENV may impact protective immune responses against ZikV.
Journal ArticleDOI
Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen
Kenneth J. Smith,Lori Garman,Jens Wrammert,Nai-Ying Zheng,J. Donald Capra,Rafi Ahmed,Patrick C. Wilson,Patrick C. Wilson +7 more
TL;DR: The approach described herein can be used to rapidly generate numerous antigen-specific hmAbs in a short time and can be completed with as little as 20 ml of human blood and in as much as 28 d when optimal.