G
Geng Lifeng
Researcher at Durham University
Publications - 15
Citations - 533
Geng Lifeng is an academic researcher from Durham University. The author has contributed to research in topics: Small molecule & Hsp90. The author has an hindex of 7, co-authored 15 publications receiving 507 citations. Previous affiliations of Geng Lifeng include Metz & G. D. Searle & Company.
Papers
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Journal ArticleDOI
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Kenneth He Huang,James Marvin Veal,Patrick Fadden,John W. Rice,Jeron Eaves,Jon-Paul Strachan,Amy F. Barabasz,Briana Foley,Barta Thomas E,Wei Ma,Melanie Silinski,Mei Hu,Jeffrey M. Partridge,Anisa Scott,Laura G. Dubois,Tiffany Freed,Paul M. Steed,Andy J. Ommen,Emilie D. Smith,Philip F. Hughes,Angela R. Woodward,Hanson Gunnar J,W. Stephen Mccall,Christopher John Markworth,Lindsay Hinkley,Matthew Jenks,Geng Lifeng,Meredith Lewis,James C. Otto,Bert Pronk,Katleen Verleysen,Steven E. Hall +31 more
TL;DR: A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library, and optimized analogues exhibited nanomolar antiproliferative activity across multiple cancer cell lines.
Patent
3 (5) -heteroaryl substituted pyrazoles as p38 kinase inhibitors
Ashok Anantanarayan,Michael Clare,Geng Lifeng,Gunnar J. Hanson,Richard A. Partis,Stealey Michael A,Richard M. Weier +6 more
TL;DR: A compound of Formula (I), or a pharmaceutically-acceptable salt or a tautomer thereof, is a compound of formula (I) where: R1 is selected from hydrido, alkyl, cyclo-alkyl, alkenyl, alkynyl, heterocyclyl, haloalkyl and heteroclylalkyl.
Journal ArticleDOI
Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90.
Barta Thomas E,James Marvin Veal,John W. Rice,Jeffrey M. Partridge,Patrick Fadden,Wei Ma,Matthew Jenks,Geng Lifeng,Hanson Gunnar J,Kenneth He Huang,Amy F. Barabasz,Briana Foley,James C. Otto,Steven E. Hall +13 more
TL;DR: X-ray data show that the scaffold binds competitively at the ATP site on Hsp90, and cellular proliferation and client assays demonstrate that members of the series are able to inhibit HSp90 at nanomolar concentrations.
Patent
Tetrahydroindolone and tetrahydroindazolone derivatives
Kenneth He Huang,Jeron Eaves,James Marvin Veal,Thomas E. Barta,Geng Lifeng,Lindsay Hinkley,Hanson Gunnar J +6 more
TL;DR: In this paper, compounds and pharmaceutically acceptable salts of Formula (I) are defined as A, Q1, Q2, Q3, R31, and R41.
Patent
Benzene, pyridine, and pyridazine derivatives
Kenneth He Huang,Jeron Eaves,Hanson Gunnar J,James Marvin Veal,Barta Thomas E,Geng Lifeng,Lindsay Hinkley +6 more
TL;DR: In this article, compounds and pharmaceutically acceptable salts of Formula (I) were defined and defined as useful in the treatment of diseases and conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like.