Genglin Jin

TL;DR: Mutations of NADP(+)-dependent isocitrate dehydrogenases encoded by IDH1 and IDH2 occur in a majority of several types of malignant gliomas.

TL;DR: Low levels of N-acetyl-aspartyl-glutamate, a common dipeptide in brain, was significantly lower in human glioma tissues containing IDH mutations than in gliomas without such mutations, and metabolic changes provide clues to the pathogenesis of tumors associated with IDH gene mutations.

TL;DR: It is found that IDH1(R132H/WT) mutation induces widespread alterations in DNA methylation, including hypermethylation of 2010 and hypomethylation of 842 CpG loci, and this data provides insight on epigenetic alterations induced byIDH1 mutations and support a causal role for IDH 1(R 132H/ WT) mutants in driving epigenetic instability in human cancer cells.

TL;DR: An anti-IDH1(R132H)-specific monoclonal antibody IMab-1 is established, which should be significantly useful for diagnosis and biological evaluation of mutation-bearing gliomas.

TL;DR: The fact that the gain of the enzymatic activity to produce 2HG is a shared feature of the IDH1 and IDH2 mutations suggests that this is an important function for these mutants in driving cancer pathogenesis.