Y
Yiping He
Researcher at Duke University
Publications - 86
Citations - 11437
Yiping He is an academic researcher from Duke University. The author has contributed to research in topics: Gene & Glioma. The author has an hindex of 31, co-authored 71 publications receiving 10222 citations. Previous affiliations of Yiping He include Howard Hughes Medical Institute & Johns Hopkins University.
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Journal ArticleDOI
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Patrick J. Killela,Zachary J. Reitman,Yuchen Jiao,Chetan Bettegowda,Nishant Agrawal,Luis A. Diaz,Allan H. Friedman,Henry S. Friedman,Gary L. Gallia,Beppino C. Giovanella,Arthur P. Grollman,Tong-Chuan He,Yiping He,Ralph H. Hruban,George I. Jallo,Nils Mandahl,Alan K. Meeker,Fredrik Mertens,George J. Netto,B.K. Ahmed Rasheed,Gregory J. Riggins,Thomas A. Rosenquist,Mark Schiffman,Ie Ming Shih,Dan Theodorescu,Michael Torbenson,Victor E. Velculescu,Tian Li Wang,Nicolas Wentzensen,Laura D. Wood,Ming Zhang,Roger E. McLendon,Darell D. Bigner,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Hai Yan +36 more
TL;DR: TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages and provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.
Journal ArticleDOI
Detection and quantification of mutations in the plasma of patients with colorectal tumors.
Frank Diehl,Meng Li,Devin Dressman,Yiping He,Dong Shen,Steve Szabo,Luis A. Diaz,Steven N. Goodman,Kerstin David,Hartmut Juhl,Kenneth W. Kinzler,Bert Vogelstein +11 more
TL;DR: Patients with advanced colorectal cancers consistently contained mutant adenomatous polyposis coli (APC) DNA molecules in their plasma, which has implications for the mechanisms through which tumor DNA is released into the circulation and for diagnostic tests based on this phenomenon.
Journal ArticleDOI
The colorectal microRNAome
Jordan M. Cummins,Yiping He,Rebecca J. Leary,Ray Pagliarini,Luis A. Diaz,Tobias Sjöblom,Omer Barad,Zvi Bentwich,Anna E. Szafranska,Emmanuel Labourier,Christopher K. Raymond,Brian S. Roberts,Hartmut Juhl,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu +15 more
TL;DR: It is suggested that the human genome contains many more miRNAs than currently identified and an experimental approach called miRNA serial analysis of gene expression (miRAGE) is developed and used to perform the largest experimental analysis of human mi RNAs to date.
Journal ArticleDOI
Altered Telomeres in Tumors with ATRX and DAXX Mutations
Christopher M. Heaphy,Roeland F. de Wilde,Yuchen Jiao,Alison P. Klein,Barish H. Edil,Chanjuan Shi,Chetan Bettegowda,Fausto J. Rodriguez,Charles G. Eberhart,Sachidanand Hebbar,G. Johan A. Offerhaus,Roger E. McLendon,B.K. Ahmed Rasheed,Yiping He,Hai Yan,Darell D. Bigner,Sueli Mieko Oba-Shinjo,Suely Kazue Nagahashi Marie,Gregory J. Riggins,Kenneth W. Kinzler,Bert Vogelstein,Ralph H. Hruban,Anirban Maitra,Nickolas Papadopoulos,Alan K. Meeker +24 more
TL;DR: The data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes, which are common in human pancreatic neuroendocrine tumors.
Journal ArticleDOI
The Genetic Landscape of the Childhood Cancer Medulloblastoma
D. Williams Parsons,D. Williams Parsons,Meng Li,Xiaosong Zhang,Siân Jones,Rebecca J. Leary,Jimmy Lin,Simina M. Boca,Hannah Carter,Josue Samayoa,Chetan Bettegowda,Chetan Bettegowda,Gary L. Gallia,George I. Jallo,Zev A. Binder,Yuri Nikolsky,James Hartigan,Doug R. Smith,Daniela S. Gerhard,Daniel W. Fults,Scott R. VandenBerg,Mitchel S. Berger,Suely Kazue Nagahashi Marie,Sueli Mieko Oba Shinjo,Carlos Clara,Peter C. Phillips,Jane E. Minturn,Jaclyn A. Biegel,Alexander R. Judkins,Adam C. Resnick,Phillip B. Storm,Tom Curran,Yiping He,B.K. Ahmed Rasheed,Henry S. Friedman,Stephen T. Keir,Roger E. McLendon,Paul A. Northcott,Michael D. Taylor,Peter C. Burger,Gregory J. Riggins,Gregory J. Riggins,Rachel Karchin,Giovanni Parmigiani,Darell D. Bigner,Hai Yan,Nick Papadopoulos,Bert Vogelstein,Kenneth W. Kinzler,Victor E. Velculescu +49 more
TL;DR: Key differences between the genetic landscapes of adult and childhood cancers are demonstrated, dysregulation of developmental pathways as an important mechanism underlying MBs is highlighted, and a role for a specific type of histone methylation in human tumorigenesis is identified.