Geoffrey B. Severin

TL;DR: This work identifies oligoribonuclease (Orn) as the primary PDE-B enzyme that removes pGpG, which is necessary to complete the final step in the c-di-GMP degradation pathway, and demonstrates that Orn is the primary source of Pde-B activity in Pseudomonas aeruginosa.

TL;DR: It is demonstrated that cGAMP activates CapV phospholipase activity to target the cell membrane and suggested that acquisition of this second messenger signaling pathway may contribute to the emergence of the El Tor biotype as the etiological agent behind the seventh cholera pandemic.

TL;DR: It is concluded that VCA0965 is capable of c-di-GMP synthesis and that the first amino acid of the GG(D/E)EF motif is more tolerant of substitutions than currently appreciated.

TL;DR: The data support a model in which flagellum assembly feeds back to control holdfast synthesis via HfiA expression in a c‐di‐GMP‐dependent manner under defined nutrient conditions, and show that flagella are not necessarily required for C. crescentus surface sensing in the absence of flow.

TL;DR: The results suggest that the c-di-GMP signaling network of V. cholerae can exist in at least three distinct states to regulate biofilm formation and motility.