G
Geoffrey Dusheiko
Researcher at University College London
Publications - 98
Citations - 5737
Geoffrey Dusheiko is an academic researcher from University College London. The author has contributed to research in topics: Hepatitis B & Hepatitis B virus. The author has an hindex of 31, co-authored 98 publications receiving 4765 citations. Previous affiliations of Geoffrey Dusheiko include University of Cambridge & Royal Free London NHS Foundation Trust.
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Journal ArticleDOI
Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis.
E. J. Heathcote,Mitchell L. Shiffman,W. G. E. Cooksley,Geoffrey Dusheiko,Sam Lee,L. Balart,Robert Reindollar,Rajender Reddy,Teresa L. Wright,A. Lin,Joseph Hoffman,J. de Pamphilis +11 more
TL;DR: In patients with chronic hepatitis C and cirrhosis or bridging fibrosis, 180 microg of peginterferon alfa-2a administered once weekly is significantly more effective than 3 million units of standard interferonAlfa- 2a administered three times weekly.
Journal ArticleDOI
Hepatitis B virus infection
Man-Fung Yuen,Ding-Shinn Chen,Ding-Shinn Chen,Geoffrey Dusheiko,Harry L.A. Janssen,Daryl T.-Y. Lau,Stephen Locarnini,Marion G. Peters,Ching-Lung Lai +8 more
TL;DR: This Primer addresses several aspects of HBV infection, including epidemiology, immune pathophysiology, diagnosis, prevention and management, including antiviral agents that directly act on viral replication and immunomodulators, such as interferon therapy.
Journal ArticleDOI
Hepatitis B cure: From discovery to regulatory approval
TL;DR: Development of standardised assays for novel biomarkers toward better defining hepatitis B virus cure should occur in parallel with development of novel antiviral and immune modulatory therapies such that approval of new treatments can be linked to the approval ofnew diagnostic assays used to measure efficacy or to predict response.
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IL-10–Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection
Abhishek Das,Gidon Ellis,Celeste Pallant,A. Ross Lopes,Pooja Khanna,Dimitra Peppa,Antony Chen,Paul A. Blair,Geoffrey Dusheiko,Upkar S. Gill,Patrick T F Kennedy,Maurizia Rossana Brunetto,Pietro Lampertico,Claudia Mauri,Mala K. Maini +14 more
TL;DR: Data reveal a novel IL-10–producing subset of B cells able to regulate T cell immunity in CHB, and their frequency correlated temporally with hepatic flares both after stimulation and directly ex vivo.
Journal ArticleDOI
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.
G. Nebbia,Dimitra Peppa,Anna Schurich,Pooja Khanna,H Singh,Yang Cheng,William Rosenberg,Geoffrey Dusheiko,Richard Gilson,Joanne Chin-Aleong,Patrick T F Kennedy,Mala K. Maini +11 more
TL;DR: Both Tim-3 and galectin-9 are increased in CHB and may contribute to the inhibition and deletion of T cells as they infiltrate the HBV-infected liver.