Georg Meisl

TL;DR: This work describes a framework, using quantitative kinetic assays and global fitting, to determine and to verify a molecular mechanism for aggregation reactions that is compatible with experimental kinetic data and provides an online platform that enables robust global analysis of kinetic data without the need for extensive programming or detailed mathematical knowledge.

TL;DR: The results reveal the key role that membrane interactions can have in triggering conversion of α-syn from its soluble state to the aggregated state that is associated with neurodegeneration and to its associated disease states.

TL;DR: This analysis sheds light on the microscopic determinants of the aggregation behavior of the principal forms of Aβ and outlines a general approach toward achieving an understanding at the molecular level of the aberrant deposition of insoluble peptides in neurodegenerative disorders.

TL;DR: A short overview of the background and recent results regarding secondary nucleation of amyloid-forming peptides and proteins, focusing in particular on the amyloids β peptide (Aβ) from Alzheimer's disease, and review experiments aimed at finding interaction partners of oligomers generated by secondaryucleation in an ongoing aggregation process.

TL;DR: It is shown that squalamine, a natural product with known anticancer and antiviral activity, dramatically affects α-synuclein aggregation in vitro and in vivo and could be a means of therapeutic intervention in Parkinson’s disease and related conditions.