Julius B. Kirkegaard

TL;DR: This work describes a framework, using quantitative kinetic assays and global fitting, to determine and to verify a molecular mechanism for aggregation reactions that is compatible with experimental kinetic data and provides an online platform that enables robust global analysis of kinetic data without the need for extensive programming or detailed mathematical knowledge.

TL;DR: This analysis sheds light on the microscopic determinants of the aggregation behavior of the principal forms of Aβ and outlines a general approach toward achieving an understanding at the molecular level of the aberrant deposition of insoluble peptides in neurodegenerative disorders.

TL;DR: It is shown that squalamine, a natural product with known anticancer and antiviral activity, dramatically affects α-synuclein aggregation in vitro and in vivo and could be a means of therapeutic intervention in Parkinson’s disease and related conditions.

TL;DR: It is shown that trodusquemine is able to inhibit multiple events in the aggregation process of α-synuclein and to provide important information about the link between such events and neurodegeneration, as it is initiated and progresses.

TL;DR: Easyworm is a user-friendly software suite coded in MATLAB that simplifies the image analysis of individual polymeric chains and the extraction of the mechanical properties of these chains.