G
Georg Wick
Researcher at Austrian Academy of Sciences
Publications - 74
Citations - 6409
Georg Wick is an academic researcher from Austrian Academy of Sciences. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 39, co-authored 74 publications receiving 6282 citations.
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Journal ArticleDOI
Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis.
Qingbo Xu,Georg Wick,Johann Willeit,M. Marosi,Stefan Kiechl,Gerhard Luef,Roman Kleindienst,Thomas M. Stulnig,Friedrich Oberhollenzer +8 more
TL;DR: The data provide the first evidence of a strong correlation between anti-hsp65 antibodies and carotid atherosclerotic lesions, suggesting that hsp65 might be involved in the pathogenesis of atherosclerosis.
Journal ArticleDOI
Is atherosclerosis an immunologically mediated disease
TL;DR: It is suggested that an autoimmune reaction against heat shock protein 60 (Hsp60), expressed by endothelial cells in areas that are subject to increased haemodynamic stress, is the initiating event in atherogenesis.
Journal ArticleDOI
Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65.
Qingbo Xu,H. Dietrich,H. J. Steiner,A. M. Gown,B. Schoel,G. Mikuz,Stefan H. E. Kaufmann,Georg Wick +7 more
TL;DR: It is concluded that an (auto)immune response to hsp may initiate the development of atherosclerosis and that a high blood cholesterol level is only one albeit a very important risk factor.
Journal ArticleDOI
Infections, immunity, and atherosclerosis: associations of antibodies to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus with immune reactions to heat-shock protein 60 and carotid or femoral atherosclerosis.
TL;DR: Strong evidence is provided for a potential atherogenic role of persistent bacterial infection, especially C pneumoniae, as indicated by serological and clinical data and a correlation between immune reactions to mHSP65 and bacterial infections in atherogenesis is demonstrated.