G
George B. McDonald
Researcher at University of Washington
Publications - 158
Citations - 16811
George B. McDonald is an academic researcher from University of Washington. The author has contributed to research in topics: Transplantation & Graft-versus-host disease. The author has an hindex of 61, co-authored 157 publications receiving 15869 citations. Previous affiliations of George B. McDonald include Anschutz Medical Campus & Fred Hutchinson Cancer Research Center.
Papers
More filters
Journal ArticleDOI
Chronic graft-versus-host syndrome in man: A long-term clinicopathologic study of 20 seattle patients
Howard M. Shulman,Keith M. Sullivan,Paul L. Weiden,George B. McDonald,Gary E. Striker,George E. Sale,Robert C. Hackman,Tsoi Ms,Rainer Storb,E. Donnall Thomas +9 more
TL;DR: Three patients had limited chronic GVHD with relatively favorable prognosis characterized by localized skin involvement and/or hepatic disease without chronic aggressive histology, but most patients, however, had extensive disease with a progressive course.
Journal ArticleDOI
Reduced mortality after allogeneic hematopoietic-cell transplantation.
Ted Gooley,Jason W. Chien,Jason W. Chien,Steven A. Pergam,Steven A. Pergam,Sangeeta Hingorani,Sangeeta Hingorani,Mohamed L. Sorror,Mohamed L. Sorror,Michael Boeckh,Michael Boeckh,Paul J. Martin,Paul J. Martin,Brenda M. Sandmaier,Brenda M. Sandmaier,Kieren A. Marr,Kieren A. Marr,Frederick R. Appelbaum,Frederick R. Appelbaum,Rainer Storb,Rainer Storb,George B. McDonald,George B. McDonald +22 more
TL;DR: A substantial reduction in the hazard of death related to allogeneic hematopoietic-cell transplantation, as well as increased long-term survival, over the past decade is found.
Journal ArticleDOI
Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression
Keith M. Sullivan,Howard M. Shulman,R Storb,Paul L. Weiden,Robert P. Witherspoon,George B. McDonald,Mark M. Schubert,K Atkinson,Thomas Ed +8 more
TL;DR: Combination immmunosuppression appears to favorably affect and, in some cases, premanently arrest the adverse natural course of extensive chronic GVHD.
Journal ArticleDOI
Venocclusive Disease of the Liver after Bone Marrow Transplantation: Diagnosis, Incidence, and Predisposing Factors
TL;DR: Hepatitis in this setting is probably of non‐A, non‐B viral etiology and represents a relative contraindication to marrow transplantation because of enhanced toxicity from conditioning chemoradiotherapy.
Journal ArticleDOI
Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease).
TL;DR: This review encompasses historical perspectives, clinical manifestations of Sinusoidal obstruction syndrome in the setting of hematopoietic cell transplantation, histologic features of centrilobular injury, and a discussion of the pathophysiology of sinusoidal injury, based on both animal and clinical investigations.