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Paul L. Weiden
Researcher at Virginia Mason Medical Center
Publications - Â 190
Citations - Â 16759
Paul L. Weiden is an academic researcher from Virginia Mason Medical Center. The author has contributed to research in topics: Transplantation & Total body irradiation. The author has an hindex of 53, co-authored 189 publications receiving 16427 citations. Previous affiliations of Paul L. Weiden include University of Washington & Argonne National Laboratory.
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Journal ArticleDOI
Chronic graft-versus-host syndrome in man: A long-term clinicopathologic study of 20 seattle patients
Howard M. Shulman,Keith M. Sullivan,Paul L. Weiden,George B. McDonald,Gary E. Striker,George E. Sale,Robert C. Hackman,Tsoi Ms,Rainer Storb,E. Donnall Thomas +9 more
TL;DR: Three patients had limited chronic GVHD with relatively favorable prognosis characterized by localized skin involvement and/or hepatic disease without chronic aggressive histology, but most patients, however, had extensive disease with a progressive course.
Journal ArticleDOI
Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts
TL;DR: The apparent antileukemic effect was more marked in patients with lymphoblastic than nonlymphoblastic leukemia, and in those who received transplants during relapse rather than during remission, and was most evident during the first 130 days after transplantation.
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Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation.
TL;DR: Recurrent leukemia is an uncommon cause of therapeutic failure in patients with chronic leukemia, and marrow transplantation is being used with increasing frequency in the treatment of acute leukemia.
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One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation.
Thomas Ed,C. D. Buckner,Banaji M,Clift Ra,Alexander Fefer,Nancy Flournoy,BW Goodell,Robert O. Hickman,Lerner Kg,Paul E. Neiman,George E. Sale,Jean E. Sanders,Jack W. Singer,M Stevens,R Storb,Paul L. Weiden +15 more
TL;DR: One hundred patients, 54 with acute myelogenous leukemia (AML) and 46 with acute lymphoblastic leukemia (ALL), considered to be in the end stages of their disease, after combination chemotherapy were treated by marrow transplantation as discussed by the authors.
Journal ArticleDOI
Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression
Keith M. Sullivan,Howard M. Shulman,R Storb,Paul L. Weiden,Robert P. Witherspoon,George B. McDonald,Mark M. Schubert,K Atkinson,Thomas Ed +8 more
TL;DR: Combination immmunosuppression appears to favorably affect and, in some cases, premanently arrest the adverse natural course of extensive chronic GVHD.