G
George Coukos
Researcher at Ludwig Institute for Cancer Research
Publications - 463
Citations - 49514
George Coukos is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Ovarian cancer & Immunotherapy. The author has an hindex of 87, co-authored 426 publications receiving 41199 citations. Previous affiliations of George Coukos include Hospital of the University of Pennsylvania & University of Glasgow.
Papers
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Journal ArticleDOI
Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure.
TL;DR: relevant players of immune cell exhaustion in cancer and HIV-1 infection are described, the best-defined hallmarks of T cell dysfunction are enumerated, and shared and divergent aspects of Tcell exhaustion and T cell activation are highlighted.
Journal ArticleDOI
miR-155 Overexpression in OT-1 CD8+ T Cells Improves Anti-Tumor Activity against Low-Affinity Tumor Antigen
Gwennaëlle C. Monnot,Amaia Martinez-Usatorre,Evripidis Lanitis,Silvia Ferreira Lopes,Wan-Chen Cheng,Wan-Chen Cheng,Ping-Chih Ho,Ping-Chih Ho,Melita Irving,Melita Irving,George Coukos,George Coukos,Alena Donda,Pedro Romero +13 more
TL;DR: It is suggested that miR-155 may optimize the antitumor activity of adoptively transferred low-affinity tumor-infiltrating lymphocytes (TILs), in particular, by rendering them more resistant to the glucose-deprived environment of solid tumors.
Book ChapterDOI
Role of Vascular Leukocytes in Ovarian Cancer Neovascularization
TL;DR: Vascular leukocytes are a new and promising novel therapeutic target for anti-angiogenic therapy and their unique mechanism merits thorough and extensive exploration in the future.
Journal ArticleDOI
A phase I/II study of chemo-immunotherapy with durvalumab (durva) and pegylated liposomal doxorubicin (PLD) in platinum-resistant recurrent ovarian cancer (PROC)
Roisin E. O'Cearbhaill,Anita Wolfer,P. DiSilvestro,David M. O'Malley,Paul Sabbatini,Lisa Shohara,Paul Schwarzenberger,Toni Ricciardi,Mary J. Macri,Aileen Ryan,Ralph Venhaus,J.K. Bryan,Phillip Wong,Krisztian Homicsko,Lana E. Kandalaft,Sylvie Rusakiewicz,Alexandre Harari,Bradley J. Monk,George Coukos +18 more
Journal Article
Gene therapy for ovarian cancer.
George Coukos,Stephen C. Rubin +1 more
TL;DR: Clinical evidence suggests that gene therapies are best suited for patients with minimal residual disease, and multimodality approaches with conventional strategies and novel therapeutic tools in various combinations will most likely prove advantageous, compared to single-modality treatments.