P
Ping-Chih Ho
Researcher at University of Lausanne
Publications - 106
Citations - 7253
Ping-Chih Ho is an academic researcher from University of Lausanne. The author has contributed to research in topics: Tumor microenvironment & Immune system. The author has an hindex of 29, co-authored 83 publications receiving 4045 citations. Previous affiliations of Ping-Chih Ho include Ludwig Institute for Cancer Research & University of Minnesota.
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Journal ArticleDOI
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
Ping-Chih Ho,Jessica D. Bihuniak,Andrew N. Macintyre,Matthew M. Staron,Xiaojing Liu,Robert A. Amezquita,Yao Chen Tsui,Yao Chen Tsui,Guoliang Cui,Goran Micevic,Jose C. Perales,Steven H. Kleinstein,E. Dale Abel,Karl L. Insogna,Stefan Feske,Jason W. Locasale,Marcus Bosenberg,Jeffrey C. Rathmell,Susan M. Kaech,Susan M. Kaech +19 more
TL;DR: New metabolic checkpoints for T cell activity are uncovered and it is demonstrated that metabolic reprogramming of tumor-reactive T cells can enhance anti-tumor T cell responses, illuminating new forms of immunotherapy.
Journal ArticleDOI
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
Daniela S. Thommen,Daniela S. Thommen,Viktor H. Koelzer,Petra Herzig,Andreas Roller,Marcel P. Trefny,Sarah Dimeloe,Anna Kiialainen,Jonathan C Hanhart,Catherine Schill,Christoph Hess,Spasenija Savic Prince,Mark Wiese,Didier Lardinois,Ping-Chih Ho,Christian Klein,Vaios Karanikas,Kirsten D. Mertz,Ton N. Schumacher,Alfred Zippelius +19 more
TL;DR: The characterization of a distinct state of tumor-reactive, PD-1-bright lymphocytes in human cancer, which only partially resembles that seen in chronic infection, provides potential avenues for therapeutic intervention.
Journal ArticleDOI
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Pu-Ste Liu,Haiping Wang,Xiaoyun Li,Tung Chao,Tony Teav,Stefan Christen,Stefan Christen,Giusy Di Conza,Wan-Chen Cheng,Chih Hung Chou,Magdalena Vavakova,Charlotte Muret,Koen Debackere,Koen Debackere,Massimiliano Mazzone,Massimiliano Mazzone,Hsien Da Huang,Sarah-Maria Fendt,Sarah-Maria Fendt,Julijana Ivanisevic,Ping-Chih Ho +20 more
TL;DR: New mechanistic regulations by which glutamine metabolism tailors the immune responses of macrophages through metabolic and epigenetic reprogramming are revealed.
Journal ArticleDOI
Regulatory circuits of T cell function in cancer
TL;DR: T cell-intrinsic molecular alterations and metabolic communication in the tumour microenvironment are discussed and identification of the underlying molecular drivers of T cell dysfunction is essential for the continued progress of cancer research and therapy.
Journal ArticleDOI
Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
Xiaoyun Li,Mathias Wenes,Pedro Romero,Stanley Ching-Cheng Huang,Sarah-Maria Fendt,Sarah-Maria Fendt,Ping-Chih Ho +6 more
TL;DR: An overview of the pathways of cancer metabolism that intersect with immunometabolism, typically resulting in immunosuppression, is provided, with a focus on how these metabolic pathways could be targeted in order to enhance anticancer immunity and immunotherapy.