J
Jose R. Conejo-Garcia
Researcher at Wistar Institute
Publications - 223
Citations - 18970
Jose R. Conejo-Garcia is an academic researcher from Wistar Institute. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 53, co-authored 164 publications receiving 15460 citations. Previous affiliations of Jose R. Conejo-Garcia include University of South Florida & University of Pennsylvania.
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Journal ArticleDOI
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Tyler J. Curiel,George Coukos,Linhua Zou,Xavier Alvarez,Pui Cheng,Peter Mottram,Melina Evdemon-Hogan,Jose R. Conejo-Garcia,Lin Zhang,Matthew E. Burow,Yun Zhu,Shuang Wei,Ilona Kryczek,Ben Daniel,Alan N. Gordon,Leann Myers,Andrew A. Lackner,Mary L. Disis,Keith L. Knutson,Lieping Chen,Weiping Zou +20 more
TL;DR: It is shown, in detailed studies of CD4+CD25+FOXP3+ Treg cells in 104 individuals affected with ovarian carcinoma, that human tumor T Reg cells suppress tumor-specific T cell immunity and contribute to growth of human tumors in vivo.
Journal ArticleDOI
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
Lin Zhang,Jose R. Conejo-Garcia,Dionyssios Katsaros,Phyllis A. Gimotty,Marco Massobrio,Giorgia Regnani,Antonis Makrigiannakis,Heidi J. Gray,Katia Schlienger,Michael N. Liebman,Stephen C. Rubin,George Coukos +11 more
TL;DR: The presence of intratumoral T cells correlates with improved clinical outcome in advanced ovarian carcinoma and was associated with increased expression of interferon-gamma, interleukin-2, and lymphocyte-attracting chemokines within the tumor.
Journal ArticleDOI
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis
Juan R. Cubillos-Ruiz,Pedro C. Silberman,Melanie R. Rutkowski,Sahil Chopra,Alfredo Perales-Puchalt,Minkyung Song,Sheng Zhang,Sarah E. Bettigole,Sarah E. Bettigole,Divya Gupta,Kevin Holcomb,Lora Hedrick Ellenson,Thomas A. Caputo,Ann-Hwee Lee,Jose R. Conejo-Garcia,Laurie H. Glimcher +15 more
TL;DR: It is shown that constitutive activation of XBP1 in tumor-associated DCs (tDCs) drives ovarian cancer (OvCa) progression by blunting anti-tumor immunity by targeting the ER stress response, thus offering a unique approach to cancer immunotherapy.
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Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A -mutated cancers
Benjamin G. Bitler,Katherine M. Aird,Azat Garipov,Hua Li,Michael Amatangelo,Andrew V. Kossenkov,David C. Schultz,Qin Liu,Ie Ming Shih,Jose R. Conejo-Garcia,David W. Speicher,Rugang Zhang +11 more
TL;DR: It is shown that inhibition of the EZH2 methyltransferase acts in a synthetic lethal manner in ARID1A-mutated ovarian cancer cells and that ARid1A mutational status correlated with response to the EzH2 inhibitor, indicating that pharmacological inhibition of EZh2 represents a novel treatment strategy for cancers involving ARIDs1A mutations.
Journal ArticleDOI
Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A.
Jose R. Conejo-Garcia,Fabian Benencia,Maria C. Courreges,Eugene Kang,Alisha Mohamed-Hadley,Ronald J. Buckanovich,David O. Holtz,Ann Jenkins,Hana Na,Lin Zhang,Daniel S. Wagner,Dionyssios Katsaros,Richard Caroll,George Coukos +13 more
TL;DR: It is shown that β-defensins and Vegf-A cooperate to promote tumor vasculogenesis by carrying out distinct tasks: β- defensins chemoattract DC precursors through CCR6, whereas Veg f-A primarily induces their endothelial-like specialization and migration to vessels, which is mediated by Vegf receptor-2.