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George J. Brewer
Researcher at University of Michigan
Publications - 336
Citations - 16168
George J. Brewer is an academic researcher from University of Michigan. The author has contributed to research in topics: Wilson's disease & Zinc. The author has an hindex of 68, co-authored 336 publications receiving 15436 citations. Previous affiliations of George J. Brewer include University of Colorado Denver & Michigan State University.
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Journal Article
Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis.
Quintin Pan,Celina G. Kleer,Kenneth L. van Golen,Jennifer Irani,Kristen M. Bottema,Carlos Bias,Magda De Carvalho,Enrique A. Mesri,Diane M. Robins,Robert D. Dick,George J. Brewer,Sofia D. Merajver +11 more
TL;DR: This study reports that copper deficiency induced by tetrathiomolybdate significantly impairs tumor growth and angiogenesis in two animal models of breast cancer: an inflammatory breast cancer xenograft in nude mice and Her2/neu cancer-prone transgenic mice.
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Hypocupremia induced by zinc therapy in adults.
TL;DR: Hypocupremia occurred in an adult with sickle cell anemia who received zinc as an antisickling agent for two years and was associated with microcytosis and relative neutropenia, which was easily corrected by copper supplementation.
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Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans
TL;DR: It is concluded that an imbalance between TH1 and TH2 cells, decreased recruitment of T naive cells, and decreased percentage of T cytolytic cells may account for decreased cell-mediated immune functions in zinc-deficient subjects.
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Serum thymulin in human zinc deficiency
TL;DR: Serum thymulin activity was decreased as a result of mild zinc deficiency and was corrected by in vivo and in vitro zinc supplementation, suggesting that this parameter was a sensitive indicator of zinc deficiency in humans.
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Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.
TL;DR: A patient with Wilson's disease is described who presented with neurologic disease, was treated with D-penicillamine, and suffered sudden neurologic deterioration coincident with therapy, suggesting that the cause of this distressing syndrome occurs frequently.