George J. Knight

TL;DR: Undiagnosed hypothyroidism in pregnant women may adversely affect their fetuses; therefore, screening for thyroid deficiency during pregnancy may be warranted.

TL;DR: Measurement of urine cotinine levels provides further evidence of an association between exposure to environmental tobacco smoke and pulmonary morbidity in children with asthma and emphasizes the need for systematic, persistent efforts to stop the exposure of children with Asthma to environmental Tobacco smoke.

TL;DR: This data indicates that serum levels of unconjugated estriol and chorionic gonadotropin, which are abnormally low and abnormally high, respectively, in women carrying fetuses affected by Down's syndrome can be detected by measuring maternal serum alpha-fetoprotein during the second trimester in the general population of pregnant women.

TL;DR: The new screening method would detect over 60% of affected pregnancies, more than double that achievable with the same amniocentesis rate in existing programmes, and could reduce the number of children born with Down's syndrome in the United Kingdom from about 900 a year to about 350 a year.

TL;DR: Screening for Down's syndrome in the first trimester is feasible, with use of measurements of pregnancy-associated protein A and either hCG or its free beta subunit in maternal serum.