J
James E. Haddow
Researcher at Brown University
Publications - 316
Citations - 18776
James E. Haddow is an academic researcher from Brown University. The author has contributed to research in topics: Pregnancy & Population. The author has an hindex of 61, co-authored 316 publications receiving 18045 citations. Previous affiliations of James E. Haddow include Boston University & LDS Hospital.
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Journal ArticleDOI
Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.
James E. Haddow,Glenn E. Palomaki,Walter C. Allan,Josephine Williams,George J. Knight,June Gagnon,Cheryl E. O’heir,Marvin L. Mitchell,Rosalie J. Hermos,Susan E. Waisbren,James D. Faix,Robert Z. Klein +11 more
TL;DR: Undiagnosed hypothyroidism in pregnant women may adversely affect their fetuses; therefore, screening for thyroid deficiency during pregnancy may be warranted.
Journal ArticleDOI
Maternal serum screening for Down's syndrome in early pregnancy.
Nicholas J. Wald,HowardS. Cuckle,J. W. Densem,K. Nanchahal,Patrick Royston,Tim Chard,James E. Haddow,G J Knight,Glenn E. Palomaki,Jacob A. Canick +9 more
TL;DR: The new screening method would detect over 60% of affected pregnancies, more than double that achievable with the same amniocentesis rate in existing programmes, and could reduce the number of children born with Down's syndrome in the United Kingdom from about 900 a year to about 350 a year.
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DNA sequencing of maternal plasma to detect Down syndrome: an international clinical validation study.
Glenn E. Palomaki,Edward M. Kloza,Geralyn Lambert-Messerlian,James E. Haddow,Louis M. Neveux,Mathias Ehrich,Dirk van den Boom,Allan T. Bombard,Allan T. Bombard,Cosmin Deciu,Wayne W. Grody,Stanley F. Nelson,Jacob A. Canick +12 more
TL;DR: Measurement of circulating cell-free DNA in maternal plasma DNA detects nearly all cases of Down syndrome at a very low false-positive rate, and can substantially reduce the need for invasive diagnostic procedures and attendant procedure-related fetal losses.
Journal ArticleDOI
Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data.
TL;DR: The dose response effect of smoking on serum cholesterol concentration suggests a gradient of increased absolute risk of coronary artery disease between light and heavy smokers.
Journal ArticleDOI
The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: methods of the EGAPP Working Group.
Steven M. Teutsch,Linda A. Bradley,Glenn E. Palomaki,James E. Haddow,Margaret Piper,Ned Calonge,W. David Dotson,Michael P. Douglas,Alfred O. Berg +8 more
TL;DR: The EGAPP processes are described and the specific methods and approaches used by the EWG are described, which include an independent, non-federal Working Group, a multidisciplinary expert panel, and a systematic review of evidence.