George Manolov

TL;DR: KNOWLEDGE of the detailed pattern of fluorescence of the normal human karyotype has enabled us to recognize, both in biopsies and in cell cultures from several Burkitt lymphomas, an extra band in one homologue of D group chromosome pair No. 14.

TL;DR: An improved resolution of the G-band pattern has been achieved in prosome analysis of the (8;14) translocation of Burkitt’s lymphoma and the concept of local prosomisation was introduced and discussed.

TL;DR: A cytogenetic study, including prophase‐prometaphase chromosome analysis, of a patient with EBV‐genome‐negative acute lymphocytic leukemia of B‐cell type with Burkitt‐type cells is presented, finding a reciprocal 8;14 translocation of exactly the same type as in Burkitt's lymphoma.

TL;DR: The new fluorescence analysis by acridin derivatives, designed by Caspersson and collaborators, has been applied to a number of Burkitt lymphomas and, as a background, to leukocyte cultures from healthy subjects, and quinacrine dihydrochloride (Q, “atebrin”) was used as fluorescent stain, which gave essentially the same chromosomal patterns as qu inacrine mustard (QM), widely used by the Casperson group.

TL;DR: High resolution chromosome analysis of bone marrow cells was performed in 15 patients with refractory anemia and a deletion of the long arm of chromosome 5 and the deletion was found to be interstitial and the breakpoints were identical in all cases.