N
Nils Mandahl
Researcher at Lund University
Publications - 428
Citations - 26216
Nils Mandahl is an academic researcher from Lund University. The author has contributed to research in topics: Karyotype & Cytogenetics. The author has an hindex of 86, co-authored 427 publications receiving 25006 citations. Previous affiliations of Nils Mandahl include University of Southern Denmark & Gdańsk Medical University.
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Journal ArticleDOI
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Patrick J. Killela,Zachary J. Reitman,Yuchen Jiao,Chetan Bettegowda,Nishant Agrawal,Luis A. Diaz,Allan H. Friedman,Henry S. Friedman,Gary L. Gallia,Beppino C. Giovanella,Arthur P. Grollman,Tong-Chuan He,Yiping He,Ralph H. Hruban,George I. Jallo,Nils Mandahl,Alan K. Meeker,Fredrik Mertens,George J. Netto,B.K. Ahmed Rasheed,Gregory J. Riggins,Thomas A. Rosenquist,Mark Schiffman,Ie Ming Shih,Dan Theodorescu,Michael Torbenson,Victor E. Velculescu,Tian Li Wang,Nicolas Wentzensen,Laura D. Wood,Ming Zhang,Roger E. McLendon,Darell D. Bigner,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Hai Yan +36 more
TL;DR: TERT and ATRX mutations were mutually exclusive, suggesting that these two genetic mechanisms confer equivalent selective growth advantages and provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.
Journal ArticleDOI
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
TL;DR: The presence of an abnormal CHOP transcript and protein in these tumours is reported and Targeting of a conserved effector domain of RNA-binding proteins to DNA may play a role in tumour formation.
Journal ArticleDOI
Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
Hai Yan,Patrick J. Killela,Zachary J. Reitman,Yuchen Jiao,Chetan Bettegowda,Nishant Agrawal,Luis A. Diaz,Allan H. Friedman,Henry S. Friedman,G.L. Gallia,B.C. Giovanella,Arthur P. Grollman,Tong-Chuan He,Yiping He,R.H. Hruban,G.I. Jallo,Nils Mandahl,Alan K. Meeker,Fredrik Mertens,George J. Netto,B.A. Rasheed,Gregory J. Riggins,T.A. Rosenquist,M. Schiffman,IeM Shih,Dan Theodorescu,M.S. Torbenson,Victor E. Velculescu,Tian Li Wang,N. Wentzensen,Laura D. Wood,Ming Zhang,Patrick Healy,Rui Yang,Bill H. Diplas,Zhaohui Wang,Paula K. Greer,Huishan Zhu,Catherine Y. Wang,Austin B. Carpenter,James E. Herndon,Roger E. McLendon,Kenneth W. Kinzler,Bert Vogelstein,N. Papadopoulos,Darell D. Bigner +45 more
TL;DR: TERT and ATRX mutations suggest that these two genetic mechanisms confer equivalent selective growth advantages and provide a biomarker that may be useful for the early detection of urinary tract and liver tumors and aid in the classification and prognostication of brain tumors.
Journal ArticleDOI
The der(17)t(x;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25
Marc Ladanyi,Man Yee Lui,Cristina R. Antonescu,Amber Krause-Boehm,Alfons Meindl,Pedram Argani,John H. Healey,Takafumi Ueda,Hideki Yoshikawa,Aurelia Meloni-Ehrig,Poul H. Sorensen,Fredrik Mertens,Nils Mandahl,Herman Van den Berghe,Raf Sciot,Paola Dal Cin,Julia A. Bridge +16 more
TL;DR: A novel sequence, designated ASPL, fused in-frame to TFE3 exon 4 (type 1 fusion) or exon 3 (type 2 fusion), supporting ASPL-TFE3 as its oncogenically significant fusion product is established and establishing the utility of this assay in the diagnosis of ASPS.
Journal ArticleDOI
Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma
Marie Pierre Simon,Florence Pedeutour,Nicolas Sirvent,J. Grosgeorge,Fabiola Minoletti,Jean Michel Coindre,Marie José Terrier-Lacombe,Nils Mandahl,Randall D. Craver,Nikolaus Blin,Gabriella Sozzi,Claude Turc-Carel,Kevin O'Brien,Darek Kedra,Ingegerd Fransson,Cecile Guilbaud,Jan P. Dumanski +16 more
TL;DR: The breakpoints from translocations and rings in DP and its juvenile form, giant cell fibroblastoma (GCF) were characterised on the genomic and RNA level and deleted exon 1 of PDGFB and release this growth factor from its normal regulation.