G
George Psomas
Researcher at Aristotle University of Thessaloniki
Publications - 152
Citations - 7553
George Psomas is an academic researcher from Aristotle University of Thessaloniki. The author has contributed to research in topics: Binding constant & Chemistry. The author has an hindex of 52, co-authored 134 publications receiving 6514 citations. Previous affiliations of George Psomas include Centre national de la recherche scientifique.
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Interaction of copper(II) with the non-steroidal anti-inflammatory drugs naproxen and diclofenac: Synthesis, structure, DNA- and albumin-binding
Filitsa Dimiza,Franc Perdih,Vassilis Tangoulis,Iztok Turel,Dimitris P. Kessissoglou,George Psomas +5 more
TL;DR: The cyclic voltammograms of the complexes recorded in the presence of CT DNA have shown that the complexes can bind to CT DNA by the intercalative binding mode which has also been verified by DNA solution viscosity measurements.
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Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives
TL;DR: The structural features of copper(II), nickel (II), cobalt (II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands and the biological activity of selected complexes are investigated.
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Biological evaluation of non-steroidal anti-inflammatory drugs-cobalt(II) complexes
Filitsa Dimiza,Athanasios N. Papadopoulos,Vassilis Tangoulis,Vassilis Psycharis,Catherine P. Raptopoulou,Dimitris P. Kessissoglou,George Psomas +6 more
TL;DR: The experimental data suggest that mefenamic acid acts as deprotonated monodentate ligand coordinated to Co(II) ion through a carboxylato oxygen as well as showing good binding propensity to human or bovine serum albumin protein having relatively high binding constant values.
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Non-steroidal antiinflammatory drug–copper(II) complexes: Structure and biological perspectives
Filitsa Dimiza,Stella Fountoulaki,Athanasios N. Papadopoulos,Christos Kontogiorgis,Vassilis Tangoulis,Catherine P. Raptopoulou,Vassilis Psycharis,Aris Terzis,Dimitris P. Kessissoglou,George Psomas +9 more
TL;DR: UV study of the interaction of the complexes with calf-thymus DNA (CT DNA) has shown that the complexes can bind to CTDNA and [bis(aqua)tetrakis(mefenamato)dicopper(II)] exhibits the highest binding constant to CT DNA.
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Novel copper(II) complex of N-propyl-norfloxacin and 1,10-phenanthroline with enhanced antileukemic and DNA nuclease activities.
Maria E. Katsarou,Eleni K. Efthimiadou,George Psomas,Alexandra Karaliota,Dionisios Vourloumis +4 more
TL;DR: It is found that the proliferation rate and viability of HL-60 cells decreased after treatment with complex 1, leading to cell death through apoptosis in a time-dependent manner, suggesting that 1 may provide a valuable tool in cancer chemotherapy.