G
George Z. Rassidakis
Researcher at Karolinska Institutet
Publications - 157
Citations - 6004
George Z. Rassidakis is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Anaplastic large-cell lymphoma & Lymphoma. The author has an hindex of 42, co-authored 137 publications receiving 5413 citations. Previous affiliations of George Z. Rassidakis include Cross Cancer Institute & University of Arkansas for Medical Sciences.
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Journal ArticleDOI
Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines: Inhibition of JAK3/STAT3 Signaling Induces Apoptosis and Cell Cycle Arrest of Colon Carcinoma Cells
Quan Lin,Raymond Lai,Lucian R. Chirieac,Changping Li,Vilmos A. Thomazy,Ioannis Grammatikakis,George Z. Rassidakis,Wei Zhang,Yasushi Fujio,Keita Kunisada,Stanley R. Hamilton,Hesham M. Amin +11 more
TL;DR: In this paper, the authors demonstrate that activated STAT3 and activated JAK3 (pSTAT3) are expressed constitutively in two colon cancer cell lines, SW480 and HT29.
Journal ArticleDOI
Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations.
Ioannis Zerdes,Alexios Matikas,Alexios Matikas,Jonas Bergh,Jonas Bergh,George Z. Rassidakis,George Z. Rassidakis,Theodoros Foukakis,Theodoros Foukakis +8 more
TL;DR: Understanding the regulation of PD-L1 in cancer will be of utmost importance for defining its role as predictive marker but also for optimizing strategies for cancer immunotherapy.
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Activation of Mammalian Target of Rapamycin Signaling Pathway Contributes to Tumor Cell Survival in Anaplastic Lymphoma Kinase–Positive Anaplastic Large Cell Lymphoma
Francisco Vega,L. Jeffrey Medeiros,Vasiliki Leventaki,Coralyn Atwell,Jeong Hee Cho-Vega,Ling Tian,Francois Xavier Claret,George Z. Rassidakis +7 more
TL;DR: Evidence is provided that mTOR signaling phosphoproteins, including mTOR, eukaryotic initiation factor 4E-binding protein-1, p70S6K, and ribosomal protein S6, are highly phosphorylated in AlK+ ALCL cell lines and tumors and that inhibition of mTOR represents a potential therapeutic strategy in ALK+ AlCL.
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Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma.
Hesham M. Amin,Timothy J. McDonnell,Yupo Ma,Quan Lin,Yasushi Fujio,Keita Kunisada,Vasiliki Leventaki,Pamela Das,George Z. Rassidakis,Cathy Cutler,L. Jeffrey Medeiros,Raymond Lai +11 more
TL;DR: The concept that STAT3 activation is pathogenetically important in ALCL cells by deregulating the expression of multiple target proteins that are involved in the control of apoptosis and cell cycle progression is supported.
Journal ArticleDOI
Survivin Expression Predicts Poorer Prognosis in Anaplastic Large-Cell Lymphoma
TL;DR: Survivin is expressed in approximately half of ALCL tumors and independently predicts unfavorable clinical outcome, and modulation of survivin expression or function may provide a novel target for experimental therapy in patients with ALCL.